Q06418.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,905 Da
NCBI Official Full Name
Tyrosine-protein kinase receptor TYRO3
NCBI Official Synonym Full Names
TYRO3 protein tyrosine kinase
NCBI Protein Information
tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase DTK; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase TIF; tyrosine-protein kinase byk
UniProt Protein Name
Tyrosine-protein kinase receptor TYRO3
UniProt Synonym Protein Names
Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF
UniProt Synonym Gene Names
UniProt Entry Name
TYRO3_HUMAN
NCBI Summary for TPP
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]
UniProt Comments for TPP
Tyro3: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TUB, TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity. Abundant in the brain and lower levels in other tissues. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Protein type: EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; TK group; Axl family
Chromosomal Location of Human Ortholog: 15q15
Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; nuclear envelope; nucleus
Molecular Function: protein binding; protein heterodimerization activity; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding
Biological Process: forebrain cell migration; negative regulation of lymphocyte activation; platelet activation; phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; vagina development; signal transduction; ovulation cycle; negative regulation of innate immune response; natural killer cell differentiation; negative regulation of inflammatory response; negative regulation of toll-like receptor signaling pathway; protein kinase B signaling cascade; spermatogenesis; negative regulation of neuron apoptosis; cell adhesion; apoptotic cell clearance; secretion by cell
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with TPP elisa kit
Diseases associated with TPP elisa kit
Organs/Tissues associated with TPP elisa kit
|