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ErbB3 elisa kit :: Cavy V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS082376 ErbB3 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ErbB3), ELISA Kit

 Also Known As   

Cavy V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 ELISA Kit

 Product Gene Name   

ErbB3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    190151
 3D Structure    ModBase 3D Structure for P21860
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 Species Reactivity    Cavy
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ErbB3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ErbB3 purchase    MBS082376 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ErbB3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ErbB3. The ELISA analytical biochemical technique of the MBS082376 kit is based on ErbB3 antibody-ErbB3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ErbB3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ErbB3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ErbB3. It may not necessarily be applicable to this product.
 NCBI GI #    12803739
 NCBI GeneID    2065
 NCBI Accession #    AAH02706.1 [Other Products]
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 UniProt Primary Accession #    P21860 [Other Products]
 UniProt Secondary Accession #    Q9BUD7; A8K6L6; B4DIK7; B4DV32; E9PDT8 [Other Products]
 UniProt Related Accession #    P21860 [Other Products]
 Molecular Weight    148,098 Da
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 NCBI Official Full Name    ERBB3 protein
 NCBI Official Synonym Full Names    v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
 NCBI Official Symbol    ERBB3 [Similar Products]
 NCBI Official Synonym Symbols   
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-3
 UniProt Synonym Protein Names   
Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
 Protein Family    Receptor tyrosine-protein kinase
 UniProt Gene Name    ERBB3 [Similar Products]
 UniProt Synonym Gene Names    HER3 [Similar Products]
 UniProt Entry Name    ERBB3_HUMAN
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 NCBI Summary for ErbB3    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ErbB3    HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.

Protein type: Protein kinase, tyrosine (receptor); Oncoprotein; Protein kinase, TK; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; TK group; EGFR family

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: extracellular space; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; lateral plasma membrane; receptor complex

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity; protein heterodimerization activity; protein-tyrosine kinase activity; growth factor binding; protein tyrosine kinase activator activity; ATP binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; wound healing; nerve growth factor receptor signaling pathway; heart development; cranial nerve development; negative regulation of cell adhesion; signal transduction; protein amino acid phosphorylation; peripheral nervous system development; negative regulation of signal transduction; regulation of cell proliferation; Schwann cell differentiation; positive regulation of phosphoinositide 3-kinase cascade; neuron apoptosis; innate immune response; negative regulation of secretion; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Lethal Congenital Contracture Syndrome 2
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 Research Articles on ErbB3    1. ERBB3 is a clear-cut marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ErbB3 elisa kitPathways associated with ErbB3 elisa kit
 Reference Product  PubMed Publications
 ERBB2 elisa kit  >791 publications with ErbB3 and ERBB2
 EGFR elisa kit  >403 publications with ErbB3 and EGFR
 EGF elisa kit  >265 publications with ErbB3 and EGF
 NRG1 elisa kit  >88 publications with ErbB3 and NRG1
 PA2G4 elisa kit  >32 publications with ErbB3 and PA2G4
 GRB2 elisa kit  >23 publications with ErbB3 and GRB2
 NRG2 elisa kit  >18 publications with ErbB3 and NRG2
 RNF41 elisa kit  >16 publications with ErbB3 and RNF41
 SHC1 elisa kit  >7 publications with ErbB3 and SHC1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of ERBB2:ERBB3 Signaling Pathway antibodies  Downregulation Of ERBB2:ERBB3 Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Diseases associated with ErbB3 elisa kitOrgans/Tissues associated with ErbB3 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >546 publications with ErbB3 and Neoplasms
 Breast Neoplasms Antibodies  >220 publications with ErbB3 and Breast Neoplasms
 Carcinoma Antibodies  >211 publications with ErbB3 and Carcinoma
 Adenocarcinoma Antibodies  >86 publications with ErbB3 and Adenocarcinoma
 Lung Neoplasms Antibodies  >72 publications with ErbB3 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >62 publications with ErbB3 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >60 publications with ErbB3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >49 publications with ErbB3 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >44 publications with ErbB3 and Neoplasm Metastasis
 Prostatic Neoplasms Antibodies  >36 publications with ErbB3 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >108 publications with ErbB3 and Lung
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