NP_005290.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,075 Da
NCBI Official Full Name
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
NCBI Official Synonym Full Names
G protein-coupled receptor 31
NCBI Protein Information
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12-(S)-HETE receptor; 12-(S)-HETE acid receptor; G-protein coupled receptor 31; probable G-protein coupled receptor 31; bA517H2.2 (G protein-coupled receptor 31); hydroxyeicosatetraenoic (HETE) acid receptor 1; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor
UniProt Protein Name
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
UniProt Synonym Protein Names
G-protein coupled receptor 31
UniProt Synonym Gene Names
UniProt Entry Name
GPR31_HUMAN
UniProt Comments for 12-HETE
GPR31: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway
Research Articles on 12-HETE
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Pathways associated with 12-HETE elisa kit
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