NP_002121.4
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,294 Da
NCBI Official Full Name
hydroxymethylglutaryl-CoA synthase, cytoplasmic
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
NCBI Official Synonym Symbols
NCBI Protein Information
hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
UniProt Protein Name
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Synonym Protein Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
UniProt Synonym Gene Names
UniProt Entry Name
HMCS1_HUMAN
UniProt Comments for HMGCS
HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.
Protein type: EC 2.3.3.10; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Carbohydrate Metabolism - butanoate; Lipid Metabolism - synthesis and degradation of ketone bodies
Chromosomal Location of Human Ortholog: 5p14-p13
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: protein homodimerization activity; hydroxymethylglutaryl-CoA synthase activity; organic acid binding; isomerase activity; drug binding
Biological Process: response to purine; response to drug; response to vitamin E; response to tellurium ion; isoprenoid biosynthetic process; male gonad development; response to lipoprotein stimulus; brain development; cellular lipid metabolic process; lipid metabolic process; liver development; cholesterol biosynthetic process; response to low light intensity
Research Articles on HMGCS
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Products associated with HMGCS elisa kit
Pathways associated with HMGCS elisa kit
Diseases associated with HMGCS elisa kit
Organs/Tissues associated with HMGCS elisa kit
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