NP_001013.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
16,060 Da
NCBI Official Full Name
40S ribosomal protein S19
NCBI Official Synonym Full Names
ribosomal protein S19
NCBI Protein Information
40S ribosomal protein S19
UniProt Protein Name
40S ribosomal protein S19
UniProt Entry Name
RS19_HUMAN
NCBI Summary for RPS19
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
UniProt Comments for RPS19
RPS19: Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1). DBA1 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S19e family.
Protein type: Ribosomal; Translation
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: focal adhesion; membrane; cytoplasm; nucleolus; ribosome; cytosol
Molecular Function: protein binding; protein homodimerization activity; fibroblast growth factor binding; structural constituent of ribosome; protein kinase binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; viral reproduction; translation; translational termination; viral infectious cycle; positive regulation of cell motility; nucleolus organization and biogenesis; maturation of SSU-rRNA; ribosomal small subunit biogenesis and assembly; monocyte chemotaxis; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cellular protein metabolic process; translational elongation; response to extracellular stimulus; mRNA catabolic process, nonsense-mediated decay; translational initiation; ribosomal small subunit assembly and maintenance; erythrocyte differentiation; gene expression; viral transcription; rRNA processing; protein tetramerization
Disease: Diamond-blackfan Anemia 1
Research Articles on RPS19
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with RPS19 elisa kit
Pathways associated with RPS19 elisa kit
Diseases associated with RPS19 elisa kit
Organs/Tissues associated with RPS19 elisa kit
|