NP_112217.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
168,460 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 12
NCBI Official Synonym Symbols
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS12; ADAMTS-12; ADAM-TS 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Synonym Gene Names
UniProt Entry Name
ATS12_HUMAN
NCBI Summary for ADAMTS12
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS12
ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.-; Protease
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity
Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; proteoglycan catabolic process; negative regulation of chondrocyte differentiation; regulation of inflammatory response
Research Articles on ADAMTS12
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Products associated with ADAMTS12 elisa kit
Pathways associated with ADAMTS12 elisa kit
Diseases associated with ADAMTS12 elisa kit
Organs/Tissues associated with ADAMTS12 elisa kit
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