NP_001257475.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,992 Da
NCBI Official Full Name
A-kinase anchor protein 13 isoform 4
NCBI Official Synonym Full Names
A-kinase anchoring protein 13
NCBI Official Synonym Symbols
BRX; LBC; p47; HA-3; Ht31; c-lbc; PRKA13; AKAP-13; AKAP-Lbc; ARHGEF13; PROTO-LB; PROTO-LBC [Similar Products]
NCBI Protein Information
A-kinase anchor protein 13
UniProt Protein Name
A-kinase anchor protein 13
UniProt Synonym Protein Names
AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; Lymphoid blast crisis oncogene; LBC oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; Protein kinase A-anchoring protein 13; PRKA13; p47
UniProt Synonym Gene Names
UniProt Entry Name
AKP13_HUMAN
NCBI Summary for AKAP13
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
UniProt Comments for AKAP13
AKAP13: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Nuclear export; GEFs, Rac/Rho; GEFs; Nuclear receptor co-regulator; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 15q24-q25
Cellular Component: cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm
Molecular Function: cAMP-dependent protein kinase activity; metal ion binding; protein binding; protein complex scaffold; protein kinase A binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; signal transducer activity
Biological Process: nerve growth factor receptor signaling pathway; nuclear export; positive regulation of apoptosis; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of protein kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
Research Articles on AKAP13
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Products associated with AKAP13 elisa kit
Pathways associated with AKAP13 elisa kit
Diseases associated with AKAP13 elisa kit
Organs/Tissues associated with AKAP13 elisa kit
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