NP_001142.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,064 Da
NCBI Official Full Name
ADP/ATP translocase 1
NCBI Official Synonym Full Names
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
NCBI Official Synonym Symbols
1; T1; ANT; AAC1; ANT1; PEO2; PEO3; ANT 1; MTDPS12 [Similar Products]
NCBI Protein Information
ADP/ATP translocase 1; ADP,ATP carrier protein 1; solute carrier family 25 member 4; heart/skeletal muscle ATP/ADP translocator; ADP,ATP carrier protein, heart/skeletal muscle; adenine nucleotide translocator 1 (skeletal muscle)
UniProt Protein Name
ADP/ATP translocase 1
UniProt Synonym Protein Names
ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4
UniProt Synonym Gene Names
UniProt Entry Name
ADT1_HUMAN
NCBI Summary for SLC25A4
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]
UniProt Comments for SLC25A4
SLC25A4: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. Belongs to the mitochondrial carrier family.
Protein type: Transporter; Mitochondrial; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q35
Cellular Component: mitochondrion; integral to plasma membrane; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; adenine transmembrane transporter activity
Biological Process: adenine transport; mitochondrial genome maintenance; apoptotic mitochondrial changes; generation of precursor metabolites and energy; viral reproduction; transport; energy reserve metabolic process; regulation of insulin secretion; transmembrane transport
Disease: Mitochondrial Dna Depletion Syndrome 12 (cardiomyopathic Type); Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2
Research Articles on SLC25A4
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Products associated with SLC25A4 elisa kit
Pathways associated with SLC25A4 elisa kit
Diseases associated with SLC25A4 elisa kit
Organs/Tissues associated with SLC25A4 elisa kit
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