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ACTN2 elisa kit :: Chicken Actinin Alpha 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS015435 ACTN2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Actinin Alpha 2 (ACTN2), ELISA Kit

 Also Known As   

Chicken Actinin Alpha 2 ELISA Kit

 Product Gene Name   

ACTN2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (236849770..236927558). Location: 1q42-q43
 OMIM    102573
 3D Structure    ModBase 3D Structure for P35609
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 Species Reactivity    Chicken
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACTN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACTN2 purchase    MBS015435 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Actinin Alpha 2 (ACTN2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACTN2. The ELISA analytical biochemical technique of the MBS015435 kit is based on ACTN2 antibody-ACTN2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACTN2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACTN2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACTN2. It may not necessarily be applicable to this product.
 NCBI GI #    507588250
 NCBI GeneID    88
 NCBI Accession #    NP_001265273.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278344.1 [Other Products]
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 UniProt Primary Accession #    P35609 [Other Products]
 UniProt Secondary Accession #    Q86TF4; Q86TI8; B1ANE4 [Other Products]
 UniProt Related Accession #    P35609 [Other Products]
 Molecular Weight    103,854 Da
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 NCBI Official Full Name    alpha-actinin-2 isoform 3
 NCBI Official Synonym Full Names    actinin, alpha 2
 NCBI Official Symbol    ACTN2 [Similar Products]
 NCBI Official Synonym Symbols   
CMD1AA
[Similar Products]
 NCBI Protein Information    alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle
 UniProt Protein Name    Alpha-actinin-2
 UniProt Synonym Protein Names   
Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
 Protein Family    Alpha-actinin
 UniProt Gene Name    ACTN2 [Similar Products]
 UniProt Entry Name    ACTN2_HUMAN
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 NCBI Summary for ACTN2    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for ACTN2    ACTN2: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the alpha-actinin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q42-q43

Cellular Component: cortical actin cytoskeleton; cytoskeleton; focal adhesion; extracellular region; dendritic spine; actin filament; pseudopodium; Z disc; cytosol; filopodium

Molecular Function: protein dimerization activity; actin filament binding; integrin binding; identical protein binding; LIM domain binding; protein binding; structural constituent of muscle; cytoskeletal protein binding; titin binding; calcium ion binding; FATZ binding; thyroid hormone receptor coactivator activity

Biological Process: focal adhesion formation; platelet activation; negative regulation of potassium ion transport; positive regulation of potassium ion transport; protein homotetramerization; muscle filament sliding; regulation of apoptosis; synaptic transmission; regulation of membrane potential; platelet degranulation; microspike biogenesis; cell adhesion; blood coagulation

Disease: Cardiomyopathy, Dilated, 1aa
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 Research Articles on ACTN2    1. This study generated the genomic sequences of K88-positive and F18-positive porcine enteroteoxigenic E. coli (ETEC) strains and examined the phylogenetic distribution of clinical porcine ETEC strains and their plasmid-associated genetic content.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACTN2 elisa kitPathways associated with ACTN2 elisa kit
 Reference Product  PubMed Publications
 TNNT2 elisa kit  >3 publications with ACTN2 and TNNT2
 LDB3 elisa kit  >3 publications with ACTN2 and LDB3
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
Diseases associated with ACTN2 elisa kitOrgans/Tissues associated with ACTN2 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8 publications with ACTN2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >4 publications with ACTN2 and Disease Models, Animal
 Neoplasms Antibodies  >3 publications with ACTN2 and Neoplasms
 Hypertrophy Antibodies  >2 publications with ACTN2 and Hypertrophy
 Hypertension Antibodies  >1 publications with ACTN2 and Hypertension
 Brain Injuries Antibodies  >1 publications with ACTN2 and Brain Injuries
 Pancreatic Neoplasms Antibodies  >1 publications with ACTN2 and Pancreatic Neoplasms
 Weight Gain Antibodies  >1 publications with ACTN2 and Weight Gain
 Kidney Diseases Antibodies  >1 publications with ACTN2 and Kidney Diseases
 Cardiomyopathy, Dilated, 1AA Antibodies  >1 publications with ACTN2 and Cardiomyopathy, Dilated, 1AA
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >37 publications with ACTN2 and Muscle
 Heart Antibodies  >17 publications with ACTN2 and Heart
 Brain Antibodies  >12 publications with ACTN2 and Brain
 Kidney Antibodies  >4 publications with ACTN2 and Kidney
 Embryonic Tissue Antibodies  >3 publications with ACTN2 and Embryonic Tissue
 Nerve Antibodies  >2 publications with ACTN2 and Nerve
 Liver Antibodies  >2 publications with ACTN2 and Liver
 Connective Tissue Antibodies  >1 publications with ACTN2 and Connective Tissue
 Testis Antibodies  >1 publications with ACTN2 and Testis
 Vascular Antibodies  >1 publications with ACTN2 and Vascular
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