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APC elisa kit :: Chicken Activated Protein C ELISA Kit

Scan QR to view Datasheet Catalog #    MBS018374 APC elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activated Protein C (APC), ELISA Kit

 Also Known As   

Chicken Activated Protein C ELISA Kit

 Product Gene Name   

APC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    114550
 3D Structure    ModBase 3D Structure for P25054
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 Species Reactivity    Chicken
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of APC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for APC purchase    MBS018374 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activated Protein C (APC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing APC. The ELISA analytical biochemical technique of the MBS018374 kit is based on APC antibody-APC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect APC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, APC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for APC. It may not necessarily be applicable to this product.
 NCBI GI #    53759122
 NCBI GeneID    324
 NCBI Accession #    NP_000029.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000038.5 [Other Products]
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 UniProt Primary Accession #    P25054 [Other Products]
 UniProt Secondary Accession #    Q15162; Q15163; Q93042; D3DT03 [Other Products]
 UniProt Related Accession #    P25054 [Other Products]
 Molecular Weight    311,646 Da
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 NCBI Official Full Name    adenomatous polyposis coli protein isoform b
 NCBI Official Synonym Full Names    adenomatous polyposis coli
 NCBI Official Symbol    APC [Similar Products]
 NCBI Official Synonym Symbols   
GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
[Similar Products]
 NCBI Protein Information    adenomatous polyposis coli protein; deleted in polyposis 2.5; adenomatosis polyposis coli tumor suppressor; protein phosphatase 1, regulatory subunit 46
 UniProt Protein Name    Adenomatous polyposis coli protein
 UniProt Synonym Protein Names   
Deleted in polyposis 2.5
 Protein Family    Adenomatous polyposis coli
 UniProt Gene Name    APC [Similar Products]
 UniProt Synonym Gene Names    DP2.5; Protein APC [Similar Products]
 UniProt Entry Name    APC_HUMAN
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 NCBI Summary for APC    This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APC    APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.

Protein type: Tumor suppressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q21-q22

Cellular Component: centrosome; tight junction; cytosol; beta-catenin destruction complex; kinetochore; nucleoplasm; cell-cell adherens junction; lamellipodium; cytoplasmic microtubule; cytoplasm; plasma membrane; nucleus; lateral plasma membrane

Molecular Function: microtubule plus-end binding; protein binding; cadherin binding; microtubule binding; gamma-catenin binding; beta-catenin binding; protein kinase regulator activity; protein kinase binding

Biological Process: positive regulation of cell adhesion; apoptosis; somatic stem cell maintenance; positive regulation of apoptosis; positive regulation of microtubule polymerization; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; cytoplasmic microtubule organization and biogenesis; anterior/posterior pattern formation; muscle maintenance; negative regulation of cell proliferation; regulation of osteoclast differentiation; hair follicle development; cytokinesis after mitosis; mitotic cell cycle spindle assembly checkpoint; positive regulation of epithelial cell differentiation; protein complex assembly; cell adhesion; cell cycle arrest; kidney development; proximal/distal pattern formation; cell structure disassembly during apoptosis; regulation of microtubule-based process; cell migration; negative regulation of odontogenesis; regulation of attachment of spindle microtubules to kinetochore; regulation of osteoblast differentiation; thymus development; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; axis specification; negative regulation of cyclin-dependent protein kinase activity; positive regulation of pseudopodium formation; axonogenesis; dorsal/ventral pattern formation; retina development in camera-type eye; positive regulation of cell division; positive regulation of protein catabolic process; regulation of nitrogen compound metabolic process; response to DNA damage stimulus; mitotic metaphase/anaphase transition; positive regulation of cell migration

Disease: Familial Adenomatous Polyposis 1; Gastric Cancer; Desmoid Disease, Hereditary; Colorectal Cancer; Hepatocellular Carcinoma
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 Research Articles on APC    1. this study reports a de novo germline mutation of APC as the causal variant in a Chinese family with inheritable colon cancer by the next generation sequencing.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APC elisa kitPathways associated with APC elisa kit
 Reference Product  PubMed Publications
 CTNNB1 elisa kit  >1765 publications with APC and CTNNB1
 AXIN1 elisa kit  >82 publications with APC and AXIN1
 AXIN2 elisa kit  >78 publications with APC and AXIN2
 MAPRE1 elisa kit  >13 publications with APC and MAPRE1
 BTRC elisa kit  >9 publications with APC and BTRC
 ARHGEF4 elisa kit  >9 publications with APC and ARHGEF4
 CTBP1 elisa kit  >4 publications with APC and CTBP1
 GSK3B elisa kit  >4 publications with APC and GSK3B
 CSNK1E elisa kit  >1 publications with APC and CSNK1E
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
Diseases associated with APC elisa kitOrgans/Tissues associated with APC elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6092 publications with APC and Neoplasms
 Gastrointestinal Neoplasms Antibodies  >3822 publications with APC and Gastrointestinal Neoplasms
 Intestinal Neoplasms Antibodies  >3572 publications with APC and Intestinal Neoplasms
 Colorectal Neoplasms Antibodies  >3363 publications with APC and Colorectal Neoplasms
 Adenomatous Polyposis Coli Antibodies  >3330 publications with APC and Adenomatous Polyposis Coli
 Colonic Neoplasms Antibodies  >2272 publications with APC and Colonic Neoplasms
 Adenoma Antibodies  >2182 publications with APC and Adenoma
 Adenomatous Polyps Antibodies  >1726 publications with APC and Adenomatous Polyps
 Inflammation Antibodies  >990 publications with APC and Inflammation
 Adenocarcinoma Antibodies  >893 publications with APC and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7042 publications with APC and Blood
 Intestine Antibodies  >1076 publications with APC and Intestine
 Bone Antibodies  >802 publications with APC and Bone
 Spleen Antibodies  >765 publications with APC and Spleen
 Vascular Antibodies  >721 publications with APC and Vascular
 Lymph Node Antibodies  >697 publications with APC and Lymph Node
 Liver Antibodies  >689 publications with APC and Liver
 Lung Antibodies  >638 publications with APC and Lung
 Brain Antibodies  >619 publications with APC and Brain
 Skin Antibodies  >514 publications with APC and Skin
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