NP_001007847.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
33,806 Da
NCBI Official Full Name
adapter molecule crk
NCBI Official Synonym Full Names
v-crk avian sarcoma virus CT10 oncogene homolog
NCBI Official Synonym Symbols
NCBI Protein Information
adapter molecule crk
UniProt Protein Name
Adapter molecule crk
UniProt Synonym Protein Names
Proto-oncogene c-Crk; p38
UniProt Entry Name
CRK_CHICK
UniProt Comments for CRK
CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex.
Protein type: Oncoprotein; Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: actin cytoskeleton; cytoplasm; plasma membrane
Molecular Function: ephrin receptor binding; protein phosphorylated amino acid binding; SH2 domain binding; SH3/SH2 adaptor activity
Biological Process: ephrin receptor signaling pathway; positive regulation of signal transduction; regulation of actin cytoskeleton organization and biogenesis; regulation of GTPase activity
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Products associated with CRK elisa kit
Pathways associated with CRK elisa kit
Diseases associated with CRK elisa kit
Organs/Tissues associated with CRK elisa kit
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