AAH75042.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,887 Da
NCBI Official Full Name
Amiloride-sensitive cation channel 1, neuronal
NCBI Official Synonym Full Names
acid-sensing (proton-gated) ion channel 2
NCBI Official Synonym Symbols
ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1 [Similar Products]
NCBI Protein Information
acid-sensing ion channel 2; brain sodium channel 1; mammalian degenerin homolog; neuronal amiloride-sensitive cation channel 1; amiloride-sensitive cation channel 1, neuronal
UniProt Protein Name
Acid-sensing ion channel 2
UniProt Synonym Protein Names
Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1; BNC1; BNaC1; Mammalian degenerin homolog
UniProt Synonym Gene Names
UniProt Entry Name
ASIC2_HUMAN
NCBI Summary for ACCN1
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
UniProt Comments for ACCN1
ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, cation; Transporter; Apoptosis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: cell soma; integral to plasma membrane; plasma membrane; dendritic spine; synapse
Molecular Function: amiloride-sensitive sodium channel activity; protein binding; ion gated channel activity; voltage-gated sodium channel activity
Biological Process: central nervous system development; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; monovalent inorganic cation transport; sensory perception of sour taste; detection of mechanical stimulus involved in sensory perception; peripheral nervous system development; synaptic transmission; positive regulation of synaptogenesis; regulation of membrane potential; sensory perception of sound; regulation of gene expression; regulation of vasoconstriction; regulation of blood coagulation; phototransduction; transmembrane transport; negative regulation of apoptosis
Research Articles on ACCN1
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Products associated with ACCN1 elisa kit
Pathways associated with ACCN1 elisa kit
Diseases associated with ACCN1 elisa kit
Organs/Tissues associated with ACCN1 elisa kit
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