NP_001245.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,720 Da
NCBI Official Full Name
cell division control protein 6 homolog
NCBI Official Synonym Full Names
cell division cycle 6
NCBI Protein Information
cell division control protein 6 homolog; p62(cdc6); CDC6-related protein; cdc18-related protein; cell division cycle 6 homolog; CDC6 cell division cycle 6 homolog
UniProt Protein Name
Cell division control protein 6 homolog
UniProt Synonym Protein Names
CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
UniProt Synonym Gene Names
UniProt Entry Name
CDC6_HUMAN
NCBI Summary for CDC6
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for CDC6
CDC6: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: nucleoplasm; Golgi apparatus; spindle pole; cytoplasm; spindle midzone; cytosol; nucleus
Molecular Function: protein binding; nucleotide binding; chromatin binding; kinase binding; ATP binding
Biological Process: positive regulation of cytokinesis; mitosis; traversing start control point of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; positive regulation of chromosome segregation; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; cell division; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle
Disease: Meier-gorlin Syndrome 5
Research Articles on CDC6
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Products associated with CDC6 elisa kit
Pathways associated with CDC6 elisa kit
Diseases associated with CDC6 elisa kit
Organs/Tissues associated with CDC6 elisa kit
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