AAP20651.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,443 Da
NCBI Official Full Name
chemokine-binding protein 2
NCBI Official Synonym Full Names
atypical chemokine receptor 2
NCBI Official Synonym Symbols
D6; hD6; CCR9; CCBP2; CCR10; CMKBR9 [Similar Products]
NCBI Protein Information
atypical chemokine receptor 2; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine binding protein 2; chemokine-binding protein 2; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61
UniProt Protein Name
Atypical chemokine receptor 2
UniProt Synonym Protein Names
C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein 2; Chemokine-binding protein D6
UniProt Synonym Gene Names
UniProt Entry Name
ACKR2_HUMAN
NCBI Summary for CCBP2
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
UniProt Comments for CCBP2
CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filament
Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; neutrophil activation; multicellular organismal development; immune response; chemotaxis; inflammatory response
Research Articles on CCBP2
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Diseases associated with CCBP2 elisa kit
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