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C4A elisa kit :: Chicken Complement Fragment 4A ELISA Kit

Scan QR to view Datasheet Catalog #    MBS045284 C4A elisa kit
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 Product Name   

Complement Fragment 4A (C4A), ELISA Kit

 Also Known As   

Chicken Complement Fragment 4A ELISA Kit

 Product Gene Name   

C4A elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 6; NC_000006.11 (31949834..31970457). Location: 6p21.3
 OMIM    120790
 3D Structure    ModBase 3D Structure for P0C0L4
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 Species Reactivity    Chicken
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of C4A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for C4A purchase    MBS045284 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Complement Fragment 4A (C4A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing C4A. The ELISA analytical biochemical technique of the MBS045284 kit is based on C4A antibody-C4A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C4A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C4A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for C4A. It may not necessarily be applicable to this product.
 NCBI GI #    67190748
 NCBI GeneID    720
 NCBI Accession #    NP_009224.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007293.2 [Other Products]
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 UniProt Primary Accession #    P0C0L4 [Other Products]
 UniProt Secondary Accession #    P01028; P78445; Q13160; Q13906; A6H8M8; A6NHJ5; A7E2V2; B0QZR6; B0V2C8; B2RUT6; B7ZVZ6 [Other Products]
 UniProt Related Accession #    P0C0L4 [Other Products]
 Molecular Weight    192,785 Da
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 NCBI Official Full Name    complement C4-A isoform 1 preproprotein
 NCBI Official Synonym Full Names    complement component 4A (Rodgers blood group)
 NCBI Official Symbol    C4A [Similar Products]
 NCBI Official Synonym Symbols   
C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2
[Similar Products]
 NCBI Protein Information    complement C4-A; acidic C4; C4A anaphylatoxin; Rodgers form of C4; acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
 UniProt Protein Name    Complement C4-A
 UniProt Synonym Protein Names   
Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
 Protein Family    Complement C4
 UniProt Gene Name    C4A [Similar Products]
 UniProt Synonym Gene Names    CO4; CPAMD2 [Similar Products]
 UniProt Entry Name    CO4A_HUMAN
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 NCBI Summary for C4A    This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for C4A    C4A: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway. Defects in C4A are the cause of complement component 4A deficiency (C4AD). A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus with or without associated glomerulonephritis. Defects in C4A are a cause of susceptibility to systemic lupus erythematosus (SLE). A chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Interindividual copy- number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: plasma membrane; extracellular region

Molecular Function: complement component C1q binding; endopeptidase inhibitor activity

Biological Process: regulation of complement activation; innate immune response; inflammatory response; complement activation, classical pathway; complement activation

Disease: Complement Component 4a Deficiency; Blood Group, Chido/rodgers System
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 Research Articles on C4A    1. Studies indicate beta-defensins (DEFB4, DEFB103, DEFB104), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor 3B (FCGR3B), and complement component C4 (C4) for copy number variation in disease association.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with C4A elisa kitDiseases associated with C4A elisa kit
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >157 publications with C4A and Lupus Erythematosus, Systemic
 Skin Diseases Antibodies  >76 publications with C4A and Skin Diseases
 Kidney Diseases Antibodies  >51 publications with C4A and Kidney Diseases
 Hyperplasia Antibodies  >43 publications with C4A and Hyperplasia
 Gonadal Disorders Antibodies  >37 publications with C4A and Gonadal Disorders
 Liver Diseases Antibodies  >32 publications with C4A and Liver Diseases
 Heart Diseases Antibodies  >31 publications with C4A and Heart Diseases
 Necrosis Antibodies  >30 publications with C4A and Necrosis
 Hepatitis Antibodies  >28 publications with C4A and Hepatitis
 Immunologic Deficiency Syndromes Antibodies  >27 publications with C4A and Immunologic Deficiency Syndromes
Organs/Tissues associated with C4A elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >448 publications with C4A and Blood
 Liver Antibodies  >63 publications with C4A and Liver
 Kidney Antibodies  >49 publications with C4A and Kidney
 Skin Antibodies  >38 publications with C4A and Skin
 Heart Antibodies  >29 publications with C4A and Heart
 Lung Antibodies  >23 publications with C4A and Lung
 Muscle Antibodies  >17 publications with C4A and Muscle
 Eye Antibodies  >16 publications with C4A and Eye
 Brain Antibodies  >16 publications with C4A and Brain
 Connective Tissue Antibodies  >10 publications with C4A and Connective Tissue
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