NP_001108603.2
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
104,786 Da
NCBI Official Full Name
complement component C6
NCBI Official Synonym Full Names
complement component 6
NCBI Protein Information
complement component C6
UniProt Protein Name
Complement component C6
UniProt Entry Name
CO6_HUMAN
NCBI Summary for C6
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
UniProt Comments for C6
C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: membrane attack complex; extracellular region
Molecular Function: protein binding
Biological Process: positive regulation of angiogenesis; in utero embryonic development; positive regulation of activation of membrane attack complex; cytolysis; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation
Disease: Complement Component 6 Deficiency
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Products associated with C6 elisa kit
Pathways associated with C6 elisa kit
Diseases associated with C6 elisa kit
Organs/Tissues associated with C6 elisa kit
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