AAA51928.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,067 Da
NCBI Official Full Name
cyclin D2, partial
NCBI Official Synonym Full Names
cyclin D2
NCBI Protein Information
G1/S-specific cyclin-D2
UniProt Protein Name
G1/S-specific cyclin-D2
UniProt Entry Name
CCND2_HUMAN
NCBI Summary for CCND2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
UniProt Comments for CCND2
CCND2: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/p27Kip1, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/p27Kip1 required for nuclear translocation and modulation of CDK4-mediated kinase activity. Belongs to the cyclin family. Cyclin D subfamily.
Protein type: Motility/polarity/chemotaxis; Cell cycle regulation
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: nucleoplasm; nuclear membrane; nucleolus; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleus; chromatin
Molecular Function: protein binding; protein kinase binding
Biological Process: positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of protein amino acid phosphorylation; cell cycle
Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus Syndrome 3
Research Articles on CCND2
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Products associated with CCND2 elisa kit
Pathways associated with CCND2 elisa kit
Diseases associated with CCND2 elisa kit
Organs/Tissues associated with CCND2 elisa kit
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