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DRD3 elisa kit :: Chicken Dopamine Receptor D3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS013204 DRD3 elisa kit
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 Product Name   

Dopamine Receptor D3 (DRD3), ELISA Kit

 Also Known As   

Chicken Dopamine Receptor D3 ELISA Kit

 Product Gene Name   

DRD3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 3; NC_000003.11 (113847557..113897899, complement). Location: 3q13.3
 OMIM    126451
 3D Structure    ModBase 3D Structure for P35462
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 Species Reactivity    Chicken
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DRD3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DRD3 purchase    MBS013204 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dopamine Receptor D3 (DRD3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DRD3. The ELISA analytical biochemical technique of the MBS013204 kit is based on DRD3 antibody-DRD3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DRD3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DRD3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for DRD3. It may not necessarily be applicable to this product.
 NCBI GI #    89191863
 NCBI GeneID    1814
 NCBI Accession #    NP_387512.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_033663.3 [Other Products]
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 UniProt Primary Accession #    P35462 [Other Products]
 UniProt Secondary Accession #    Q4VBM8; A1A4V5 [Other Products]
 UniProt Related Accession #    P35462 [Other Products]
 Molecular Weight    44,225 Da
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 NCBI Official Full Name    D(3) dopamine receptor isoform e
 NCBI Official Synonym Full Names    dopamine receptor D3
 NCBI Official Symbol    DRD3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    D(3) dopamine receptor; D(3) dopamine receptor; essential tremor 1; dopamine D3 receptor
 UniProt Protein Name    D(3) dopamine receptor
 UniProt Synonym Protein Names   
Dopamine D3 receptor
 Protein Family    D(3) dopamine receptor
 UniProt Gene Name    DRD3 [Similar Products]
 UniProt Entry Name    DRD3_HUMAN
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 NCBI Summary for DRD3    This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
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 UniProt Comments for DRD3    DRD3: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 3q13.3

Cellular Component: cell projection; endocytic vesicle; apical part of cell; integral to plasma membrane; plasma membrane

Molecular Function: dopamine D2 receptor-like receptor activity; protein domain specific binding; protein binding; dopamine binding; drug binding; D1 dopamine receptor binding

Biological Process: synaptic transmission, dopaminergic; regulation of lipid metabolic process; prepulse inhibition; musculoskeletal movement, spinal reflex action; response to morphine; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; regulation of dopamine secretion; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; learning and/or memory; behavioral response to cocaine; positive regulation of cell proliferation; renin-angiotensin regulation of blood volume; visual learning; circadian regulation of gene expression; negative regulation of blood pressure; negative regulation of sodium:hydrogen antiporter activity; dopamine receptor, adenylate cyclase activating pathway; response to drug; positive regulation of cytokinesis; positive regulation of dopamine receptor signaling pathway; negative regulation of protein secretion; negative regulation of protein kinase B signaling cascade; positive regulation of mitosis; regulation of cAMP metabolic process; negative regulation of adenylate cyclase activity; response to amphetamine; regulation of dopamine uptake; regulation of multicellular organism growth; social behavior; learning; arachidonic acid secretion; response to cocaine; regulation of circadian sleep/wake cycle, sleep; negative regulation of oligodendrocyte differentiation; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; acid secretion; negative regulation of dopamine receptor signaling pathway; response to ethanol; G-protein coupled receptor internalization; positive regulation of transcription from RNA polymerase II promoter

Disease: Schizophrenia; Tremor, Hereditary Essential, 1
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 Research Articles on DRD3    1. the DRD3 ser9gly variant influences in vivo DA release in the context of unpredicted reward, a finding with potentially important implications for the pathophysiology and treatment of addiction and mood disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DRD3 elisa kitPathways associated with DRD3 elisa kit
 Reference Product  PubMed Publications
 RGS4 elisa kit  >4 publications with DRD3 and RGS4
 NPY elisa kit  >3 publications with DRD3 and NPY
 APP elisa kit  >2 publications with DRD3 and APP
 SST elisa kit  >2 publications with DRD3 and SST
 ADCY5 elisa kit  >1 publications with DRD3 and ADCY5
 POMC elisa kit  >1 publications with DRD3 and POMC
 PDYN elisa kit  >1 publications with DRD3 and PDYN
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
Diseases associated with DRD3 elisa kitOrgans/Tissues associated with DRD3 elisa kit
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >429 publications with DRD3 and Mental Disorders
 Schizophrenia Antibodies  >258 publications with DRD3 and Schizophrenia
 Nervous System Diseases Antibodies  >208 publications with DRD3 and Nervous System Diseases
 Substance-Related Disorders Antibodies  >145 publications with DRD3 and Substance-Related Disorders
 Movement Disorders Antibodies  >117 publications with DRD3 and Movement Disorders
 Dyskinesias Antibodies  >74 publications with DRD3 and Dyskinesias
 Basal Ganglia Diseases Antibodies  >66 publications with DRD3 and Basal Ganglia Diseases
 Parkinsonian Disorders Antibodies  >51 publications with DRD3 and Parkinsonian Disorders
 Dyskinesia, Drug-Induced Antibodies  >46 publications with DRD3 and Dyskinesia, Drug-Induced
 Bipolar Disorder Antibodies  >45 publications with DRD3 and Bipolar Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >569 publications with DRD3 and Brain
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