NP_990841.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
91,577 Da
NCBI Official Full Name
fibroblast growth factor receptor 1
NCBI Official Synonym Full Names
fibroblast growth factor receptor 1
NCBI Protein Information
fibroblast growth factor receptor 1
UniProt Protein Name
Fibroblast growth factor receptor 1
UniProt Synonym Protein Names
Basic fibroblast growth factor receptor 1; Tyrosine kinase receptor CEK1
UniProt Synonym Gene Names
UniProt Entry Name
FGFR1_CHICK
UniProt Comments for FGFR1
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation ().
Research Articles on FGFR1
Precautions
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Disclaimer
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Pathways associated with FGFR1 elisa kit
Diseases associated with FGFR1 elisa kit
Organs/Tissues associated with FGFR1 elisa kit
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