NP_005242.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,719 Da
NCBI Official Full Name
forkhead box protein C2
NCBI Official Synonym Full Names
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
NCBI Protein Information
forkhead box protein C2; MFH-1,mesenchyme forkhead 1; transcription factor FKH-14; mesenchyme fork head protein 1; forkhead-related protein FKHL14; forkhead, Drosophila, homolog-like 14
UniProt Protein Name
Forkhead box protein C2
UniProt Synonym Protein Names
Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14
UniProt Synonym Gene Names
UniProt Entry Name
FOXC2_HUMAN
NCBI Summary for FOXC2
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXC2
FOXC2: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2); also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment. Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN). LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD). LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).
Protein type: Transcription factor; DNA-binding; Cell development/differentiation; Apoptosis
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; chromatin DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; collagen fibril organization; neural crest cell development; heart development; positive regulation of transcription, DNA-dependent; response to hormone stimulus; cardiac muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; ureteric bud development; lymphangiogenesis; ventricular cardiac muscle morphogenesis; mesoderm development; regulation of blood vessel size; Notch signaling pathway; somitogenesis; ossification; camera-type eye development; positive regulation of cell adhesion mediated by integrin; regulation of organ growth; embryonic viscerocranium morphogenesis; patterning of blood vessels; regulation of transcription from RNA polymerase II promoter; paraxial mesodermal cell fate commitment; insulin receptor signaling pathway; embryonic heart tube development; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; vascular endothelial growth factor receptor signaling pathway; metanephros development
Disease: Lymphedema-distichiasis Syndrome
Research Articles on FOXC2
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Pathways associated with FOXC2 elisa kit
Diseases associated with FOXC2 elisa kit
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