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G0S2 elisa kit :: Chicken G0/G1 switch gene 2 (G0S2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS700405
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $575 +1 FREE 8GB USB
96-Strip-Wells  /  $835 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,040 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,755 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

G0/G1 switch gene 2 (G0S2), ELISA Kit

★Popular Item★
 Also Known As   

Chicken G0/G1 switch gene 2, G0S2 ELISA Kit

 Product Synonym Names    Chicken G0/G1 switch gene 2 (G0S2) ELISA Kit; G0/G1 switch gene 2 (G0S2)
 Product Gene Name   

G0S2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS700405 Testing Data    Testing Data PDF
 OMIM    614447
 3D Structure    ModBase 3D Structure for P27469
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 Species Reactivity    Chicken
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 Assay Type    Competitive
 Detection Range    31.2 pg/ml-500 pg/ml
 Sensitivity    15.6 pg/ml
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of G0S2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for G0S2 purchase    MBS700405 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the G0/G1 switch gene 2 (G0S2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2 pg/ml-500 pg/ml in biological research samples containing G0S2, with an estimated sensitivity of 15.6 pg/ml. The ELISA analytical biochemical technique of the MBS700405 kit is based on G0S2 antibody-G0S2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect G0S2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, G0S2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for G0S2 elisa kit

   Introduction: PPARs (peroxisome-proliferator-activated receptors) alpha, beta/delta and gamma are a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis. By comparing liver mRNAs of wild-type and PPARalpha-null mice using microarrays, a novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2), was identified. Hepatic expression of G0S2 was up-regulated by fasting and by the PPARalpha agonist Wy14643 in a PPARalpha-dependent manner. Surprisingly, the G0S2 mRNA level was highest in brown and white adipose tissue and was greatly up-regulated during mouse 3T3-L1 and human SGBS (Simpson-Golabi-Behmel syndrome) adipogenesis. Transactivation, gel shift and chromatin immunoprecipitation assays indicated that G0S2 is a direct PPARgamma and probable PPARalpha target gene with a functional PPRE (PPAR-responsive element) in its promoter. Up-regulation of G0S2 mRNA seemed to be specific for adipogenesis, and was not observed during osteogenesis or myogenesis. In 3T3-L1 fibroblasts, expression of G0S2 was associated with growth arrest, which is required for 3T3-L1 adipogenesis. Together, these data indicate that G0S2 is a novel target gene of PPARs that may be involved in adipocyte differentiation.

Principle of the Assay: This assay employs the direct competitive inhibition enzyme immunoassay technique. An antibody specific for G0S2 has been pre-coated onto a microplate. Add G0S2 (Standards or samples) to the well, and then add Biotin conjugated G0S2. A competitive inhibition reaction is launched between G0S2 (Standards or samples) and Biotin conjugated G0S2 with the G0S2 antibody. Then add the HRP-avidin to each well. The substrate solutions are added to the wells, respectively. And the color develops in opposite to the amount of G0S2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of G0S2 elisa kit    G0S2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS700405. Click to request current manual
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NCBI/Uniprot data below describe general gene information for G0S2. It may not necessarily be applicable to this product.
 NCBI GI #    7657104
 NCBI GeneID    50486
 NCBI Accession #    NP_056529.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015714.3 [Other Products]
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 UniProt Primary Accession #    P27469 [Other Products]
 UniProt Secondary Accession #    Q6FGC8 [Other Products]
 UniProt Related Accession #    P27469 [Other Products]
 Molecular Weight    11,321 Da
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 NCBI Official Full Name    G0/G1 switch protein 2
 NCBI Official Synonym Full Names    G0/G1 switch 2
 NCBI Official Symbol    G0S2 [Similar Products]
 NCBI Protein Information    G0/G1 switch protein 2; G0/G1switch 2; G0/G1 switch regulatory protein 2
 UniProt Protein Name    G0/G1 switch protein 2
 UniProt Synonym Protein Names   
G0/G1 switch regulatory protein 2; Putative lymphocyte G0/G1 switch gene
 Protein Family    G0/G1 switch protein
 UniProt Gene Name    G0S2 [Similar Products]
 UniProt Entry Name    G0S2_HUMAN
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 UniProt Comments for G0S2    Function: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.1 PublicationManual assertion based on experiment in:Ref.7
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 Research Articles on G0S2    1. reelin expression is altered by Abeta leading to impaired reelin signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with G0S2 elisa kitDiseases associated with G0S2 elisa kit
 Products by Pathway  Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >7 publications with G0S2 and Fatty Liver
 Liver Diseases Antibodies  >6 publications with G0S2 and Liver Diseases
 Carcinoma Antibodies  >6 publications with G0S2 and Carcinoma
 Necrosis Antibodies  >5 publications with G0S2 and Necrosis
 Neoplasms, Experimental Antibodies  >4 publications with G0S2 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >4 publications with G0S2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >3 publications with G0S2 and Liver Neoplasms
 Lung Diseases Antibodies  >3 publications with G0S2 and Lung Diseases
 Hyperglycemia Antibodies  >3 publications with G0S2 and Hyperglycemia
 Cardiovascular Diseases Antibodies  >3 publications with G0S2 and Cardiovascular Diseases
Organs/Tissues associated with G0S2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with G0S2 and Blood
 Adipose Tissue Antibodies  >11 publications with G0S2 and Adipose Tissue
 Liver Antibodies  >5 publications with G0S2 and Liver
 Muscle Antibodies  >3 publications with G0S2 and Muscle
 Lung Antibodies  >3 publications with G0S2 and Lung
 Skin Antibodies  >2 publications with G0S2 and Skin
 Heart Antibodies  >2 publications with G0S2 and Heart
 Bone Marrow Antibodies  >2 publications with G0S2 and Bone Marrow
 Intestine Antibodies  >2 publications with G0S2 and Intestine
 Mouth Antibodies  >1 publications with G0S2 and Mouth
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