AAH09797.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,232 Da
NCBI Official Full Name
GATA1 protein
NCBI Official Synonym Full Names
GATA binding protein 1 (globin transcription factor 1)
NCBI Official Synonym Symbols
GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1 [Similar Products]
NCBI Protein Information
erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; erythroid transcription factor 1; globin transcription factor 1; nuclear factor, erythroid 1; transcription factor GATA1
UniProt Protein Name
Erythroid transcription factor
UniProt Synonym Protein Names
Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
GATA1_HUMAN
NCBI Summary for GATA1
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
UniProt Comments for GATA1
GATA1: Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: nucleoplasm; transcription factor complex; transcriptional repressor complex; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin DNA binding; sequence-specific DNA binding; p53 binding; DNA bending activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; erythrocyte development; embryonic hemopoiesis; in utero embryonic development; megakaryocyte differentiation; positive regulation of erythrocyte differentiation; male gonad development; eosinophil differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of bone mineralization; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of osteoblast proliferation; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; platelet formation; blood coagulation; basophil differentiation; negative regulation of apoptosis
Disease: Thrombocytopenia With Beta-thalassemia, X-linked; Anemia, X-linked, With Or Without Neutropenia And/or Platelet Abnormalities; Down Syndrome; Thrombocytopenia, X-linked, With Or Without Dyserythropoietic Anemia
Research Articles on GATA1
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Products associated with GATA1 elisa kit
Diseases associated with GATA1 elisa kit
Disease Name |
Pubmed Publications |
THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA Antibodies |
>679 publications with GATA1 and THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA |
Leukemia Antibodies |
>406 publications with GATA1 and Leukemia |
Leukemia, Myeloid, Acute Antibodies |
>252 publications with GATA1 and Leukemia, Myeloid, Acute |
Bone Marrow Diseases Antibodies |
>229 publications with GATA1 and Bone Marrow Diseases |
Down Syndrome Antibodies |
>182 publications with GATA1 and Down Syndrome |
Anemia Antibodies |
>152 publications with GATA1 and Anemia |
Thrombocytopenia Antibodies |
>68 publications with GATA1 and Thrombocytopenia |
Chromosome Aberrations Antibodies |
>46 publications with GATA1 and Chromosome Aberrations |
Cell Transformation, Neoplastic Antibodies |
>31 publications with GATA1 and Cell Transformation, Neoplastic |
Inflammation Antibodies |
>28 publications with GATA1 and Inflammation |
Organs/Tissues associated with GATA1 elisa kit
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