CAA30521.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,398 Da
NCBI Official Full Name
GDH
NCBI Official Synonym Full Names
glutamate dehydrogenase 1
NCBI Protein Information
glutamate dehydrogenase 1, mitochondrial; GDH 1; glutamate dehydrogenase (NAD(P)+)
UniProt Protein Name
Glutamate dehydrogenase 1, mitochondrial
UniProt Synonym Gene Names
UniProt Entry Name
DHE3_HUMAN
NCBI Summary for GDH
This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]
UniProt Comments for GDH
GLUD1: May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Homohexamer. Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein type: EC 1.4.1.3; Energy Metabolism - nitrogen; Amino Acid Metabolism - arginine and proline; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; Oxidoreductase; Other Amino Acids Metabolism - D-Glutamine and D-glutamate
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm
Molecular Function: identical protein binding; protein binding; glutamate dehydrogenase activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; ADP binding; ATP binding
Biological Process: glutamate catabolic process; substantia nigra development; positive regulation of insulin secretion; glutamine metabolic process; glutamate biosynthetic process; amino acid biosynthetic process
Disease: Hyperinsulinemic Hypoglycemia, Familial, 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with GDH elisa kit
Diseases associated with GDH elisa kit
Organs/Tissues associated with GDH elisa kit
|