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ITPA elisa kit :: Chicken Inosine Triphosphatase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS090800 ITPA elisa kit
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 Product Name   

Inosine Triphosphatase (ITPA), ELISA Kit

 Also Known As   

Chicken Inosine Triphosphatase ELISA Kit

 Product Gene Name   

ITPA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    147520
 3D Structure    ModBase 3D Structure for Q9BY32
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 Species Reactivity    Chicken
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ITPA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ITPA purchase    MBS090800 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Inosine Triphosphatase (ITPA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ITPA. The ELISA analytical biochemical technique of the MBS090800 kit is based on ITPA antibody-ITPA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ITPA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ITPA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ITPA. It may not necessarily be applicable to this product.
 NCBI GI #    30173120
 NCBI GeneID    3704
 NCBI Accession #    Q9BY32.2 [Other Products]
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 UniProt Primary Accession #    Q9BY32 [Other Products]
 UniProt Secondary Accession #    O14878; Q5JWH4; Q9BYN1; Q9BYX0; Q9H3H8; A2A2N2; A4UIM5; B2BCH7 [Other Products]
 UniProt Related Accession #    Q9BY32 [Other Products]
 Molecular Weight    21,446 Da
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 NCBI Official Full Name    Inosine triphosphate pyrophosphatase
 NCBI Official Synonym Full Names    inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
 NCBI Official Symbol    ITPA [Similar Products]
 NCBI Official Synonym Symbols   
My049; C20orf37; dJ794I6.3; HLC14-06-P
[Similar Products]
 NCBI Protein Information    inosine triphosphate pyrophosphatase; ITPase; NTPase; inosine triphosphatase-A; putative oncogene protein HLC14-06-P; nucleoside-triphosphate diphosphatase; non-standard purine NTP pyrophosphatase; non-canonical purine NTP pyrophosphatase; inosine triphosphate pyrophosphohydrolase
 UniProt Protein Name    Inosine triphosphate pyrophosphatase
 UniProt Synonym Protein Names   
Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase; Putative oncogene protein hlc14-06-p
 UniProt Gene Name    ITPA [Similar Products]
 UniProt Synonym Gene Names    C20orf37; ITPase; Inosine triphosphatase; NTPase [Similar Products]
 UniProt Entry Name    ITPA_HUMAN
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 NCBI Summary for ITPA    This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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 UniProt Comments for ITPA    ITPA: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPA are the cause of inosine triphosphate pyrophosphohydrolase deficiency (ITPAD). It is a common inherited trait characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes and also leukocytes and fibroblasts. The pathological consequences of ITPA deficiency, if any, are unknown. However, it might have pharmacogenomic implications and be related to increased drug toxicity of purine analog drugs. Three different human populations have been reported with respect to their ITPase activity: high, mean (25% of high) and low activity. The variant Thr-32 is associated with complete loss of enzyme activity, may be by altering the local secondary structure of the protein. Heterozygotes for this polymorphism have 22.5% of the control activity: this is consistent with a dimeric structure of the enzyme. Belongs to the HAM1 NTPase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - pyrimidine; EC; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine; Hydrolase

Chromosomal Location of Human Ortholog: 20p

Cellular Component: cytoplasm; cytosol

Molecular Function: metal ion binding; nucleotide binding

Biological Process: deoxyribonucleoside triphosphate catabolic process; nucleobase, nucleoside and nucleotide metabolic process; ITP catabolic process; chromosome organization and biogenesis

Disease: Inosine Triphosphatase Deficiency
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 Research Articles on ITPA    1. ITPA protects against ribavirin-induced anemia, but is not associated with sustained virological response rate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ITPA elisa kitPathways associated with ITPA elisa kit
 Reference Product  PubMed Publications
 TPMT elisa kit  >37 publications with ITPA and TPMT
 IMPDH1 elisa kit  >2 publications with ITPA and IMPDH1
 IMPDH2 elisa kit  >2 publications with ITPA and IMPDH2
 NME1 elisa kit  >1 publications with ITPA and NME1
 ADSS elisa kit  >1 publications with ITPA and ADSS
 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
Diseases associated with ITPA elisa kitOrgans/Tissues associated with ITPA elisa kit
 Disease Name  Pubmed Publications
 Anemia Antibodies  >60 publications with ITPA and Anemia
 Anemia, Hemolytic Antibodies  >23 publications with ITPA and Anemia, Hemolytic
 Neoplasms Antibodies  >23 publications with ITPA and Neoplasms
 Leukemia Antibodies  >20 publications with ITPA and Leukemia
 Thrombocytopenia Antibodies  >9 publications with ITPA and Thrombocytopenia
 Drug-Related Side Effects and Adverse Reactions Antibodies  >8 publications with ITPA and Drug-Related Side Effects and Adverse Reactions
 Hemolysis Antibodies  >8 publications with ITPA and Hemolysis
 Congenital Abnormalities Antibodies  >7 publications with ITPA and Congenital Abnormalities
 Leukopenia Antibodies  >7 publications with ITPA and Leukopenia
 Necrosis Antibodies  >6 publications with ITPA and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >61 publications with ITPA and Blood
 Liver Antibodies  >40 publications with ITPA and Liver
 Skin Antibodies  >14 publications with ITPA and Skin
 Brain Antibodies  >13 publications with ITPA and Brain
 Kidney Antibodies  >8 publications with ITPA and Kidney
 Heart Antibodies  >6 publications with ITPA and Heart
 Muscle Antibodies  >5 publications with ITPA and Muscle
 Lung Antibodies  >5 publications with ITPA and Lung
 Bone Antibodies  >5 publications with ITPA and Bone
 Eye Antibodies  >3 publications with ITPA and Eye
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