AAA41446.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
304,286 Da
NCBI Official Full Name
inositol triphosphate receptor subtype 3
NCBI Official Synonym Full Names
inositol 1,4,5-trisphosphate receptor, type 3
NCBI Protein Information
inositol 1,4,5-trisphosphate receptor type 3; IP3R 3; IP3R-3; insP3R3; IP3 receptor; type 3 InsP3 receptor; inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; type 3 inositol 1,4,5-trisphosphate receptor
UniProt Protein Name
Inositol 1,4,5-trisphosphate receptor type 3
UniProt Synonym Protein Names
IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor
UniProt Synonym Gene Names
UniProt Entry Name
ITPR3_RAT
NCBI Summary for IP3
receptor for Inositol 1,4,5-trisphosphate (IP3); involved in second messenger signaling [RGD, Feb 2006]
UniProt Comments for IP3
IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family.
Protein type: Membrane protein, multi-pass; Channel, calcium; Channel, ligand-gated; Membrane protein, integral
Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; dendrite; integral to membrane; nuclear envelope; nucleoplasm; membrane; cell soma; perinuclear region of cytoplasm; apical part of cell; cytoplasm; plasma membrane; nucleolus; nucleus; receptor complex; brush border; myelin sheath
Molecular Function: inositol 1,3,4,5 tetrakisphosphate binding; inositol hexakisphosphate binding; calcium ion transmembrane transporter activity; calcium ion binding; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; sensory perception of umami taste; inositol phosphate-mediated signaling; sensory perception of sweet taste; protein heterooligomerization; calcium ion transport; sensory perception of bitter taste; response to calcium ion; memory; protein homooligomerization
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Pathways associated with IP3 elisa kit
Diseases associated with IP3 elisa kit
Organs/Tissues associated with IP3 elisa kit
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