NP_001138472.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
116,038 Da
NCBI Official Full Name
integrin alpha-V isoform 3
NCBI Official Synonym Full Names
integrin, alpha V
NCBI Protein Information
integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
UniProt Protein Name
Integrin alpha-V
UniProt Synonym Protein Names
Vitronectin receptor subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
ITAV_HUMAN
NCBI Summary for ITGalphaV
This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]
UniProt Comments for ITGalphaV
ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q31-q32
Cellular Component: filopodium membrane; focal adhesion; cell surface; membrane; integral to plasma membrane; microvillus membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane
Molecular Function: viral receptor activity; voltage-gated calcium channel activity; protein binding; opsonin binding; insulin-like growth factor I binding; protease binding; protein kinase C binding; extracellular matrix binding; transforming growth factor beta binding; fibronectin binding; metal ion binding
Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; positive regulation of cell adhesion; cell-matrix adhesion; negative chemotaxis; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; cell adhesion; cell growth; integrin-mediated signaling pathway; cell migration; negative regulation of lipoprotein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-substrate adhesion; heterotypic cell-cell adhesion; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; blood coagulation; vascular endothelial growth factor receptor signaling pathway; leukocyte migration; apoptotic cell clearance; positive regulation of cell migration
Research Articles on ITGalphaV
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Pathways associated with ITGalphaV elisa kit
Diseases associated with ITGalphaV elisa kit
Organs/Tissues associated with ITGalphaV elisa kit
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