CAA34947.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,062 Da
NCBI Official Full Name
leukocyte antigen F
NCBI Official Synonym Full Names
major histocompatibility complex, class I, F
NCBI Official Synonym Symbols
HLAF; CDA12; HLA-5.4; HLA-CDA12 [Similar Products]
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain F; HLA F antigen; leukocyte antigen F; HLA class I molecule; MHC class Ib antigen; MHC class I antigen F
UniProt Protein Name
HLA class I histocompatibility antigen, alpha chain F
UniProt Synonym Protein Names
CDA12; HLA F antigen; Leukocyte antigen F; MHC class I antigen F
UniProt Synonym Gene Names
UniProt Entry Name
HLAF_HUMAN
NCBI Summary for HLA-E
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA-E
HLA-F: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell surface; membrane; early endosome membrane; endoplasmic reticulum; plasma membrane; MHC class I protein complex
Molecular Function: peptide antigen binding; TAP1 binding; TAP2 binding; receptor binding
Biological Process: regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I
Research Articles on HLA-E
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Products associated with HLA-E elisa kit
Pathways associated with HLA-E elisa kit
Diseases associated with HLA-E elisa kit
Organs/Tissues associated with HLA-E elisa kit
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