NP_005507.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,157 Da
NCBI Official Full Name
HLA class I histocompatibility antigen, alpha chain E
NCBI Official Synonym Full Names
major histocompatibility complex, class I, E
NCBI Official Synonym Symbols
MHC; QA1; EA1.2; EA2.1; HLA-6.2 [Similar Products]
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain
UniProt Protein Name
HLA class I histocompatibility antigen, alpha chain E
UniProt Synonym Protein Names
MHC class I antigen E
UniProt Synonym Gene Names
UniProt Entry Name
HLAE_HUMAN
NCBI Summary for HLA-E
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA-E
HLA-E: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. Belongs to the MHC class I family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell surface; early endosome membrane; plasma membrane; MHC class I protein complex
Molecular Function: peptide antigen binding; MHC class I protein binding; beta-2-microglobulin binding; receptor binding
Biological Process: regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; regulation of natural killer cell mediated immunity; positive regulation of natural killer cell mediated immunity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protection from natural killer cell mediated cytotoxicity; antigen processing and presentation of endogenous peptide antigen via MHC class Ib
Research Articles on HLA-E
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Products associated with HLA-E elisa kit
Pathways associated with HLA-E elisa kit
Diseases associated with HLA-E elisa kit
Organs/Tissues associated with HLA-E elisa kit
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