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MTHFR elisa kit :: Chicken MTHFR ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2507478
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTHFR, ELISA Kit

★Popular Item★
 Also Known As   

Chicken MTHFR (Methylenetetrahydrofolate Reductase) ELISA Kit

 Product Gene Name   

MTHFR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    236250
 3D Structure    ModBase 3D Structure for P42898
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 Species Reactivity    Chicken
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 Specificity    This kit recognizes natural and recombinant Chicken MTHFR. No significant cross-reactivity or interference between Chicken MTHFR and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    3.906-250pg/mL
 Sensitivity    2.344pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MTHFR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MTHFR purchase    MBS2507478 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the MTHFR, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.906-250pg/mL in biological research samples containing MTHFR, with an estimated sensitivity of 2.344pg/mL. The ELISA analytical biochemical technique of the MBS2507478 kit is based on MTHFR antibody-MTHFR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MTHFR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MTHFR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for MTHFR elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Chicken MTHFR concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to MTHFR. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for MTHFR and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain MTHFR, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of MTHFR. You can calculate the concentration of MTHFR in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of MTHFR elisa kit    MTHFR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2507478. Click to request current manual
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NCBI/Uniprot data below describe general gene information for MTHFR. It may not necessarily be applicable to this product.
 NCBI GI #    87240000
 NCBI GeneID    4524
 NCBI Accession #    NP_005948.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005957.4 [Other Products]
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 UniProt Primary Accession #    P42898 [Other Products]
 UniProt Secondary Accession #    Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2; B2R7A6 [Other Products]
 UniProt Related Accession #    P42898 [Other Products]
 Molecular Weight    78,965 Da
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 NCBI Official Full Name    methylenetetrahydrofolate reductase
 NCBI Official Synonym Full Names    methylenetetrahydrofolate reductase (NAD(P)H)
 NCBI Official Symbol    MTHFR [Similar Products]
 NCBI Protein Information    methylenetetrahydrofolate reductase; 5,10-methylenetetrahydrofolate reductase (NADPH)
 UniProt Protein Name    Methylenetetrahydrofolate reductase
 Protein Family    Methylenetetrahydrofolate reductase
 UniProt Gene Name    MTHFR [Similar Products]
 UniProt Entry Name    MTHR_HUMAN
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 NCBI Summary for MTHFR    The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]
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 UniProt Comments for MTHFR    MTHFR: Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine. Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD). MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia, developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders. Defects in MTHFR may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (FS-NTD). The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Belongs to the methylenetetrahydrofolate reductase family.

Protein type: Energy Metabolism - methane; EC 1.5.1.20; Oxidoreductase; Cofactor and Vitamin Metabolism - one carbon pool by folate

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: neuron projection; cytosol

Molecular Function: FAD binding; NADP binding; methylenetetrahydrofolate reductase (NADPH) activity

Biological Process: response to drug; amino acid metabolic process; vitamin metabolic process; methionine biosynthetic process; blood circulation; response to folic acid; response to vitamin B2; response to hypoxia; S-adenosylmethionine metabolic process; homocysteine metabolic process; one-carbon compound metabolic process; folic acid metabolic process; water-soluble vitamin metabolic process

Disease: Schizophrenia; Thrombophilia Due To Thrombin Defect; Neural Tube Defects, Folate-sensitive; Homocystinuria Due To Deficiency Of N(5,10)-methylenetetrahydrofolate Reductase Activity
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 Research Articles on MTHFR    1. The MTHFR A1298C polymorphism is not associated with recurrent pregnancy loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MTHFR elisa kitPathways associated with MTHFR elisa kit
 Reference Product  PubMed Publications
 MTR elisa kit  >273 publications with MTHFR and MTR
 MTRR elisa kit  >266 publications with MTHFR and MTRR
 TYMS elisa kit  >128 publications with MTHFR and TYMS
 MTHFD1 elisa kit  >74 publications with MTHFR and MTHFD1
 SHMT1 elisa kit  >54 publications with MTHFR and SHMT1
 MTHFD2 elisa kit  >4 publications with MTHFR and MTHFD2
 AMT elisa kit  >2 publications with MTHFR and AMT
 SHMT2 elisa kit  >1 publications with MTHFR and SHMT2
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
Diseases associated with MTHFR elisa kitOrgans/Tissues associated with MTHFR elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1883 publications with MTHFR and Cardiovascular Diseases
 Vascular Diseases Antibodies  >1670 publications with MTHFR and Vascular Diseases
 Nervous System Diseases Antibodies  >1130 publications with MTHFR and Nervous System Diseases
 Hematologic Diseases Antibodies  >656 publications with MTHFR and Hematologic Diseases
 Venous Thrombosis Antibodies  >508 publications with MTHFR and Venous Thrombosis
 Stroke Antibodies  >425 publications with MTHFR and Stroke
 Coronary Disease Antibodies  >372 publications with MTHFR and Coronary Disease
 Neural Tube Defects Antibodies  >325 publications with MTHFR and Neural Tube Defects
 Colorectal Neoplasms Antibodies  >283 publications with MTHFR and Colorectal Neoplasms
 Skin Diseases Antibodies  >195 publications with MTHFR and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2464 publications with MTHFR and Blood
 Brain Antibodies  >339 publications with MTHFR and Brain
 Heart Antibodies  >325 publications with MTHFR and Heart
 Kidney Antibodies  >187 publications with MTHFR and Kidney
 Liver Antibodies  >187 publications with MTHFR and Liver
 Bone Antibodies  >118 publications with MTHFR and Bone
 Lung Antibodies  >98 publications with MTHFR and Lung
 Stomach Antibodies  >85 publications with MTHFR and Stomach
 Muscle Antibodies  >72 publications with MTHFR and Muscle
 Skin Antibodies  >58 publications with MTHFR and Skin
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