NP_000247.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
140,703 Da
NCBI Official Full Name
myosin-binding protein C, cardiac-type
NCBI Official Synonym Full Names
myosin binding protein C, cardiac
NCBI Official Synonym Symbols
FHC; CMH4; CMD1MM; LVNC10; MYBP-C [Similar Products]
NCBI Protein Information
myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform
UniProt Protein Name
Myosin-binding protein C, cardiac-type
UniProt Synonym Protein Names
C-protein, cardiac muscle isoform
UniProt Synonym Gene Names
UniProt Entry Name
MYPC3_HUMAN
NCBI Summary for MYBPC3
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYBPC3
MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.
Protein type: Myosin-binding
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: sarcomere; striated muscle thick filament; cytosol; A band
Molecular Function: identical protein binding; ATPase activator activity; myosin binding; structural constituent of muscle; metal ion binding; titin binding; actin binding; myosin heavy chain binding
Biological Process: heart morphogenesis; positive regulation of ATPase activity; regulation of heart rate; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; myosin filament assembly; cell adhesion; cardiac muscle contraction; muscle filament sliding
Disease: Left Ventricular Noncompaction 10; Cardiomyopathy, Familial Hypertrophic, 4
Research Articles on MYBPC3
Precautions
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Products associated with MYBPC3 elisa kit
Pathways associated with MYBPC3 elisa kit
Diseases associated with MYBPC3 elisa kit
Disease Name |
Pubmed Publications |
Cardiomyopathy, Hypertrophic Antibodies |
>219 publications with MYBPC3 and Cardiomyopathy, Hypertrophic |
Heart Diseases Antibodies |
>212 publications with MYBPC3 and Heart Diseases |
Cardiomyopathies Antibodies |
>199 publications with MYBPC3 and Cardiomyopathies |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>86 publications with MYBPC3 and Cardiomyopathy, Hypertrophic, Familial |
Hypertrophy Antibodies |
>84 publications with MYBPC3 and Hypertrophy |
Death, Sudden Antibodies |
>54 publications with MYBPC3 and Death, Sudden |
Death, Sudden, Cardiac Antibodies |
>51 publications with MYBPC3 and Death, Sudden, Cardiac |
Cardiomegaly Antibodies |
>38 publications with MYBPC3 and Cardiomegaly |
Cardiomyopathy, Dilated Antibodies |
>30 publications with MYBPC3 and Cardiomyopathy, Dilated |
Cardiomyopathy, Familial Hypertrophic, 4 Antibodies |
>26 publications with MYBPC3 and Cardiomyopathy, Familial Hypertrophic, 4 |
Organs/Tissues associated with MYBPC3 elisa kit
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