NP_078781.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,109 Da
NCBI Official Full Name
NADPH oxidase 5 isoform 1
NCBI Official Synonym Full Names
NADPH oxidase, EF-hand calcium binding domain 5
NCBI Protein Information
NADPH oxidase 5
UniProt Protein Name
NADPH oxidase 5
UniProt Entry Name
NOX5_HUMAN
NCBI Summary for NOX5
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for NOX5
NOX5: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.6.3.-; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q23
Cellular Component: endoplasmic reticulum; integral to membrane
Molecular Function: protein binding; FAD binding; superoxide-generating NADPH oxidase activity; heme binding; hydrogen ion channel activity; calcium ion binding; NADP binding
Biological Process: cell proliferation; proton transport; regulation of fusion of sperm to egg plasma membrane; apoptosis; endothelial cell proliferation; cytokinesis; regulation of proton transport; angiogenesis; cytokine secretion; superoxide release
Research Articles on NOX5
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Products associated with NOX5 elisa kit
Diseases associated with NOX5 elisa kit
Organs/Tissues associated with NOX5 elisa kit
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