NP_009103.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,863 Da
NCBI Official Full Name
nuclear pore complex protein Nup50 isoform b
NCBI Official Synonym Full Names
nucleoporin 50kDa
NCBI Protein Information
nuclear pore complex protein Nup50; 50 kDa nucleoporin; nuclear pore-associated protein 60L; nucleoporin 50kD; nucleoporin Nup50
UniProt Protein Name
Nuclear pore complex protein Nup50
UniProt Synonym Protein Names
50 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50
UniProt Synonym Gene Names
UniProt Entry Name
NUP50_HUMAN
NCBI Summary for NUP50
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NUP50
NUP50: Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear import; Nucleoporin
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nuclear pore
Molecular Function: protein binding
Biological Process: mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; protein transport; intracellular transport; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport
Research Articles on NUP50
Precautions
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Products associated with NUP50 elisa kit
Pathways associated with NUP50 elisa kit
Diseases associated with NUP50 elisa kit
Organs/Tissues associated with NUP50 elisa kit
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