NP_001180286.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,255 Da
NCBI Official Full Name
nuclear pore glycoprotein p62
NCBI Official Synonym Full Names
nucleoporin 62kDa
NCBI Protein Information
nuclear pore glycoprotein p62; 62 kDa nucleoporin; nucleoporin 62kD; nucleoporin Nup62
UniProt Protein Name
Nuclear pore glycoprotein p62
UniProt Synonym Protein Names
62 kDa nucleoporin; Nucleoporin Nup62
UniProt Entry Name
NUP62_HUMAN
NCBI Summary for NUP62
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
UniProt Comments for NUP62
NUP62: Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI); also known as infantile bilateral striatal necrosis (IBSN) or familial striatal degeneration. SNDI is a neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy and mental retardation. Belongs to the nucleoporin NSP1/NUP62 family.
Protein type: Adaptor/scaffold; Nucleoporin
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: nucleocytoplasmic shuttling complex; pore complex; spindle pole; nuclear membrane; intracellular membrane-bound organelle; cytoplasm; nuclear envelope; nuclear pore; ribonucleoprotein complex
Molecular Function: protein binding; ubiquitin binding; receptor signaling complex scaffold activity; structural constituent of nuclear pore; PTB domain binding; SH2 domain binding; chromatin binding; thyroid hormone receptor binding; nucleocytoplasmic transporter activity
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; cell death; negative regulation of MAP kinase activity; mRNA transport; hormone-mediated signaling; viral reproduction; positive regulation of transcription, DNA-dependent; mitotic nuclear envelope disassembly; regulation of signal transduction; nucleocytoplasmic transport; pathogenesis; glucose transport; viral infectious cycle; negative regulation of cell proliferation; protein transport; cell surface receptor linked signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; negative regulation of programmed cell death; negative regulation of Ras protein signal transduction; viral transcription; transmembrane transport; regulation of Ras protein signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; cell aging; hexose transport; carbohydrate metabolic process; gene expression; mitotic cell cycle; negative regulation of apoptosis
Disease: Striatonigral Degeneration, Infantile
Research Articles on NUP62
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Products associated with NUP62 elisa kit
Pathways associated with NUP62 elisa kit
Diseases associated with NUP62 elisa kit
Organs/Tissues associated with NUP62 elisa kit
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