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PKCG elisa kit :: Chicken Protein Kinase C Gamma ELISA Kit

Scan QR to view Datasheet Catalog #    MBS024662 PKCG elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein Kinase C Gamma (PKCG), ELISA Kit

 Also Known As   

Chicken Protein Kinase C Gamma ELISA Kit

 Product Gene Name   

PKCG elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 19; NC_000019.9 (54385467..54410901). Location: 19q13.4
 OMIM    176980
 3D Structure    ModBase 3D Structure for P05129
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 Species Reactivity    Chicken
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PKCG elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PKCG purchase    MBS024662 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protein Kinase C Gamma (PKCG) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PKCG. The ELISA analytical biochemical technique of the MBS024662 kit is based on PKCG antibody-PKCG antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PKCG antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PKCG. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PKCG. It may not necessarily be applicable to this product.
 NCBI GI #    13384594
 NCBI GeneID    5582
 NCBI Accession #    NP_002730.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002739.3 [Other Products]
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 UniProt Primary Accession #    P05129 [Other Products]
 UniProt Related Accession #    P05129 [Other Products]
 Molecular Weight    78,448 Da
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 NCBI Official Full Name    protein kinase C gamma type
 NCBI Official Synonym Full Names    protein kinase C, gamma
 NCBI Official Symbol    PRKCG [Similar Products]
 NCBI Official Synonym Symbols   
PKCC; PKCG; SCA14; PKC-gamma
[Similar Products]
 NCBI Protein Information    protein kinase C gamma type
 UniProt Protein Name    Protein kinase C gamma type
 Protein Family    Protein kinase
 UniProt Gene Name    PRKCG [Similar Products]
 UniProt Synonym Gene Names    PKCG; PKC-gamma [Similar Products]
 UniProt Entry Name    KPCG_HUMAN
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 NCBI Summary for PKCG    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
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 UniProt Comments for PKCG    PKCG: a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase. Expressed in the brain and spinal cord where its localization is restricted to neurons. Several neuronal functions, including long term potentiation and depression (LTP&LTD) specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects have been associated with neurodegenerative disorder spinocerebellar ataxia-14. Plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GLUR4 and NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor MGLUR5 and phosphorylates NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43, resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53 and promotes p53-dependent apoptosis in response to DNA damage. Interacts with GRIA4. Interacts with CDCP1. Interacts with TP53INP1 and p53. Expressed in Purkinje cells of the cerebellar cortex.

Protein type: Kinase, protein; EC 2.7.11.13; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: perinuclear region of cytoplasm; dendrite; plasma membrane; intercellular junction; nucleus; cytosol

Molecular Function: protein kinase C activity; zinc ion binding; protein serine/threonine/tyrosine kinase activity; calcium-dependent protein kinase C activity; ATP binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; positive regulation of mismatch repair; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; rhythmic process; response to morphine; response to pain; regulation of circadian rhythm; signal transduction; protein amino acid phosphorylation; synaptic transmission; learning and/or memory; phospholipase C activation; innate immune response; chemosensory behavior; negative regulation of protein ubiquitination; negative regulation of neuron apoptosis; negative regulation of protein catabolic process; blood coagulation; phosphorylation; regulation of response to food

Disease: Spinocerebellar Ataxia 14
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 Research Articles on PKCG    1. Exome sequencing of large, 5-generational British kindred finds a novel p.Arg26Gly mutation in the PRKCG gene causing familial spinocerebellar ataxia 14.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PKCG elisa kitPathways associated with PKCG elisa kit
 Reference Product  PubMed Publications
 PRKCA elisa kit  >99 publications with PKCG and PRKCA
 PRKCD elisa kit  >24 publications with PKCG and PRKCD
 SRC elisa kit  >9 publications with PKCG and SRC
 PRKCB elisa kit  >2 publications with PKCG and PRKCB
 HRAS elisa kit  >1 publications with PKCG and HRAS
 GRIN2B elisa kit  >1 publications with PKCG and GRIN2B
 GJA1 elisa kit  >1 publications with PKCG and GJA1
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Diseases associated with PKCG elisa kitOrgans/Tissues associated with PKCG elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >153 publications with PKCG and Nervous System Diseases
 Brain Diseases Antibodies  >80 publications with PKCG and Brain Diseases
 Pain Antibodies  >75 publications with PKCG and Pain
 Ataxia Antibodies  >52 publications with PKCG and Ataxia
 Hyperalgesia Antibodies  >37 publications with PKCG and Hyperalgesia
 Spinocerebellar Ataxias Antibodies  >35 publications with PKCG and Spinocerebellar Ataxias
 Cardiovascular Diseases Antibodies  >24 publications with PKCG and Cardiovascular Diseases
 Mental Disorders Antibodies  >23 publications with PKCG and Mental Disorders
 Brain Ischemia Antibodies  >15 publications with PKCG and Brain Ischemia
 Eye Diseases Antibodies  >15 publications with PKCG and Eye Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >229 publications with PKCG and Brain
 Eye Antibodies  >35 publications with PKCG and Eye
 Kidney Antibodies  >14 publications with PKCG and Kidney
 Ovary Antibodies  >4 publications with PKCG and Ovary
 Stomach Antibodies  >3 publications with PKCG and Stomach
 Testis Antibodies  >2 publications with PKCG and Testis
 Thymus Antibodies  >1 publications with PKCG and Thymus
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