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SDF1alpha elisa kit :: Chicken Stromal Cell Derived Factor 1alpha ELISA Kit

Scan QR to view Datasheet Catalog #    MBS020435 SDF1alpha elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Stromal Cell Derived Factor 1alpha (SDF1alpha), ELISA Kit

 Also Known As   

Chicken Stromal Cell Derived Factor 1alpha ELISA Kit

 Product Gene Name   

SDF1alpha elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    600835
 3D Structure    ModBase 3D Structure for P48061
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 Species Reactivity    Chicken
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SDF1alpha elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SDF1alpha purchase    MBS020435 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Stromal Cell Derived Factor 1alpha (SDF1alpha) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SDF1alpha. The ELISA analytical biochemical technique of the MBS020435 kit is based on SDF1alpha antibody-SDF1alpha antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SDF1alpha antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SDF1alpha. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SDF1alpha. It may not necessarily be applicable to this product.
 NCBI GI #    76563933
 NCBI GeneID    6387
 NCBI Accession #    NP_001029058.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033886.2 [Other Products]
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 UniProt Primary Accession #    P48061 [Other Products]
 UniProt Secondary Accession #    Q2L985; Q2L986; Q2L988; Q5IT36; Q6ICW0; Q9H554; B2R4G0; E7EVL0; H7BYN8 [Other Products]
 UniProt Related Accession #    P48061 [Other Products]
 Molecular Weight    10,666 Da
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 NCBI Official Full Name    stromal cell-derived factor 1 isoform gamma
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 12
 NCBI Official Symbol    CXCL12 [Similar Products]
 NCBI Official Synonym Symbols   
IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
[Similar Products]
 NCBI Protein Information    stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor
 UniProt Protein Name    Stromal cell-derived factor 1
 UniProt Synonym Protein Names   
C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor
 UniProt Gene Name    CXCL12 [Similar Products]
 UniProt Synonym Gene Names    SDF1; SDF1A; SDF1B; SDF-1; hSDF-1; IRH; hIRH; PBSF [Similar Products]
 UniProt Entry Name    SDF1_HUMAN
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 NCBI Summary for SDF1alpha    This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for SDF1alpha    CXCL12: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T- cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N- terminus of CXCR7. Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen. Belongs to the intercrine alpha (chemokine CxC) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q11.1

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: growth factor activity; chemokine receptor binding; chemokine activity; CXCR chemokine receptor binding; receptor binding

Biological Process: response to peptide hormone stimulus; positive regulation of dopamine secretion; positive regulation of cell adhesion; adult locomotory behavior; blood circulation; neuron migration; motor axon guidance; chemotaxis; signal transduction; germ cell development; induction of positive chemotaxis; T cell proliferation; response to radiation; germ cell migration; cell adhesion; organ regeneration; response to virus; regulation of actin polymerization and/or depolymerization; patterning of blood vessels; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; response to heat; response to mechanical stimulus; ameboidal cell migration; positive regulation of axon extension involved in axon guidance; response to hypoxia; immune response; positive regulation of endothelial cell proliferation; telencephalon cell migration

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on SDF1alpha    1. The CXCL12-CXCR4 axis may influence the expression of VEGFR3 in urothelial bladder carcinoma and promote tumor recurrence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SDF1alpha elisa kitPathways associated with SDF1alpha elisa kit
 Reference Product  PubMed Publications
 CXCR4 elisa kit  >3186 publications with SDF1alpha and CXCR4
 CCR5 elisa kit  >289 publications with SDF1alpha and CCR5
 CXCR7 elisa kit  >260 publications with SDF1alpha and CXCR7
 CXCR3 elisa kit  >122 publications with SDF1alpha and CXCR3
 HIF1A elisa kit  >73 publications with SDF1alpha and HIF1A
 CCR4 elisa kit  >41 publications with SDF1alpha and CCR4
 STAT3 elisa kit  >36 publications with SDF1alpha and STAT3
 JAK2 elisa kit  >18 publications with SDF1alpha and JAK2
 VAV1 elisa kit  >17 publications with SDF1alpha and VAV1
 SDC4 elisa kit  >5 publications with SDF1alpha and SDC4
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
Diseases associated with SDF1alpha elisa kitOrgans/Tissues associated with SDF1alpha elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1463 publications with SDF1alpha and Neoplasms
 Cardiovascular Diseases Antibodies  >544 publications with SDF1alpha and Cardiovascular Diseases
 Inflammation Antibodies  >532 publications with SDF1alpha and Inflammation
 Neoplasm Metastasis Antibodies  >368 publications with SDF1alpha and Neoplasm Metastasis
 HIV Infections Antibodies  >260 publications with SDF1alpha and HIV Infections
 Heart Diseases Antibodies  >253 publications with SDF1alpha and Heart Diseases
 Breast Neoplasms Antibodies  >252 publications with SDF1alpha and Breast Neoplasms
 Ischemia Antibodies  >221 publications with SDF1alpha and Ischemia
 Neoplasm Invasiveness Antibodies  >218 publications with SDF1alpha and Neoplasm Invasiveness
 Necrosis Antibodies  >211 publications with SDF1alpha and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1430 publications with SDF1alpha and Bone
 Bone Marrow Antibodies  >1311 publications with SDF1alpha and Bone Marrow
 Vascular Antibodies  >1047 publications with SDF1alpha and Vascular
 Brain Antibodies  >473 publications with SDF1alpha and Brain
 Muscle Antibodies  >347 publications with SDF1alpha and Muscle
 Lung Antibodies  >312 publications with SDF1alpha and Lung
 Heart Antibodies  >285 publications with SDF1alpha and Heart
 Liver Antibodies  >263 publications with SDF1alpha and Liver
 Embryonic Tissue Antibodies  >206 publications with SDF1alpha and Embryonic Tissue
 Nerve Antibodies  >165 publications with SDF1alpha and Nerve
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