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TRAIL elisa kit :: Chicken Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand ELISA Kit

Scan QR to view Datasheet Catalog #    MBS025606 TRAIL elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), ELISA Kit

 Also Known As   

Chicken Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand ELISA Kit

 Product Gene Name   

TRAIL elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    603598
 3D Structure    ModBase 3D Structure for P50591
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 Species Reactivity    Chicken
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TRAIL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TRAIL purchase    MBS025606 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TRAIL. The ELISA analytical biochemical technique of the MBS025606 kit is based on TRAIL antibody-TRAIL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TRAIL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TRAIL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for TRAIL. It may not necessarily be applicable to this product.
 NCBI GI #    4507593
 NCBI GeneID    8743
 NCBI Accession #    NP_003801.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003810.3 [Other Products]
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 UniProt Primary Accession #    P50591 [Other Products]
 UniProt Secondary Accession #    A1Y9B3 [Other Products]
 UniProt Related Accession #    P50591 [Other Products]
 Molecular Weight    32,509 Da
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 10 isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 10
 NCBI Official Symbol    TNFSF10 [Similar Products]
 NCBI Official Synonym Symbols   
TL2; APO2L; CD253; TRAIL; Apo-2L
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 10
 UniProt Synonym Protein Names   
Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand
 UniProt Gene Name    TNFSF10 [Similar Products]
 UniProt Synonym Gene Names    APO2L; TRAIL; Apo-2L [Similar Products]
 UniProt Entry Name    TNF10_HUMAN
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 NCBI Summary for TRAIL    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for TRAIL    TRAIL: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26

Cellular Component: extracellular space; integral to plasma membrane; extracellular region

Molecular Function: protein binding; metal ion binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; cell-cell signaling; positive regulation of apoptosis; apoptosis; male gonad development; positive regulation of caspase activity; immune response; signal transduction; response to insulin stimulus
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 Research Articles on TRAIL    1. These results suggest that TRAIL inhibits VEGF-induced angiogenesis by increasing caspase-8 activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 activation and endothelial cell cytotoxicity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TRAIL elisa kitPathways associated with TRAIL elisa kit
 Reference Product  PubMed Publications
 TNFRSF10B elisa kit  >2722 publications with TRAIL and TNFRSF10B
 CASP8 elisa kit  >1284 publications with TRAIL and CASP8
 FADD elisa kit  >624 publications with TRAIL and FADD
 TNFRSF10A elisa kit  >552 publications with TRAIL and TNFRSF10A
 CFLAR elisa kit  >252 publications with TRAIL and CFLAR
 TNFRSF11B elisa kit  >171 publications with TRAIL and TNFRSF11B
 TNFRSF10C elisa kit  >117 publications with TRAIL and TNFRSF10C
 TRADD elisa kit  >62 publications with TRAIL and TRADD
 CASP10 elisa kit  >61 publications with TRAIL and CASP10
 TNFRSF10D elisa kit  >52 publications with TRAIL and TNFRSF10D
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Dimerization Of Procaspase-8 Pathway antibodies  Dimerization Of Procaspase-8 Pathway Diagram
Diseases associated with TRAIL elisa kitOrgans/Tissues associated with TRAIL elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3775 publications with TRAIL and Necrosis
 Neoplasms Antibodies  >3102 publications with TRAIL and Neoplasms
 Leukemia Antibodies  >458 publications with TRAIL and Leukemia
 Colorectal Neoplasms Antibodies  >337 publications with TRAIL and Colorectal Neoplasms
 Liver Diseases Antibodies  >330 publications with TRAIL and Liver Diseases
 Breast Neoplasms Antibodies  >303 publications with TRAIL and Breast Neoplasms
 Liver Neoplasms Antibodies  >285 publications with TRAIL and Liver Neoplasms
 Lung Neoplasms Antibodies  >283 publications with TRAIL and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >270 publications with TRAIL and Neoplasms, Experimental
 Inflammation Antibodies  >262 publications with TRAIL and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1082 publications with TRAIL and Blood
 Liver Antibodies  >445 publications with TRAIL and Liver
 Lung Antibodies  >379 publications with TRAIL and Lung
 Prostate Antibodies  >315 publications with TRAIL and Prostate
 Brain Antibodies  >229 publications with TRAIL and Brain
 Vascular Antibodies  >187 publications with TRAIL and Vascular
 Kidney Antibodies  >151 publications with TRAIL and Kidney
 Skin Antibodies  >128 publications with TRAIL and Skin
 Bone Marrow Antibodies  >106 publications with TRAIL and Bone Marrow
 Muscle Antibodies  >76 publications with TRAIL and Muscle
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