NP_989750.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
104,436 Da
NCBI Official Full Name
retinoblastoma-associated protein
NCBI Official Synonym Full Names
retinoblastoma 1
NCBI Protein Information
retinoblastoma-associated protein; rb; pRb; p104; retinoblastoma 1 (including osteosarcoma)
UniProt Protein Name
Retinoblastoma-associated protein
UniProt Synonym Protein Names
p104; pRb; Rb
UniProt Synonym Gene Names
UniProt Entry Name
RB_CHICK
UniProt Comments for RB1
Function: Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting chromatin-modifying enzymes to promoters
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Disclaimer
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Products associated with RB1 elisa kit
Pathways associated with RB1 elisa kit
Diseases associated with RB1 elisa kit
Organs/Tissues associated with RB1 elisa kit
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