NP_001131124.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
85,511 Da
NCBI Official Full Name
catenin beta-1
NCBI Protein Information
catenin beta-1
UniProt Protein Name
Catenin beta-1
UniProt Synonym Protein Names
Beta-catenin
UniProt Entry Name
CTNB1_CANLF
UniProt Comments for CTNNB1
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle ().
Research Articles on CTNNB1
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Products associated with CTNNB1 elisa kit
Pathways associated with CTNNB1 elisa kit
Diseases associated with CTNNB1 elisa kit
Organs/Tissues associated with CTNNB1 elisa kit
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