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NFKB1 elisa kit :: Dog Nuclear factor NF-kappa-B p105 subunit ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2887275 NFKB1 elisa kit
Unit / Price
48-Strip-Wells  /  $430 +1 FREE 8GB USB
96-Strip-Wells  /  $570 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,515 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,520 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nuclear factor NF-kappa-B p105 subunit (NFKB1), ELISA Kit

 Also Known As   

Dog Nuclear factor NF-kappa-B p105 subunit ELISA Kit

 Product Synonym Names    Nuclear factor NF-kappa-B p105 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NFKB1
 Product Gene Name   

NFKB1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2887275 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for Q6F3J0
 Species Reactivity    Dog
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 Detection Range    0.312-20 ng/mL
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NFKB1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NFKB1 purchase    MBS2887275 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Nuclear factor NF-kappa-B p105 subunit (NFKB1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312-20 ng/mL in biological research samples containing NFKB1. The ELISA analytical biochemical technique of the MBS2887275 kit is based on NFKB1 antibody-NFKB1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NFKB1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NFKB1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Sample Manual Insert of MBS2887275. Click to request current manual
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NCBI/Uniprot data below describe general gene information for NFKB1. It may not necessarily be applicable to this product.
 NCBI GI #    50979190
 NCBI GeneID    442859
 NCBI Accession #    NP_001003344.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001003344.1 [Other Products]
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 UniProt Primary Accession #    Q6F3J0 [Other Products]
 UniProt Secondary Accession #    F1PM82 [Other Products]
 UniProt Related Accession #    Q6F3J0 [Other Products]
 Molecular Weight    105,631 Da
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 NCBI Official Full Name    nuclear factor NF-kappa-B p105 subunit
 NCBI Official Symbol    NFKB1 [Similar Products]
 NCBI Protein Information    nuclear factor NF-kappa-B p105 subunit
 UniProt Protein Name    Nuclear factor NF-kappa-B p105 subunit
 UniProt Synonym Protein Names   
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 Protein Family    Nuclear factor
 UniProt Gene Name    NFKB1 [Similar Products]
 UniProt Entry Name    NFKB1_CANLF
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 UniProt Comments for NFKB1    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105 ().
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 Research Articles on NFKB1    1. The dog p65 and cat p65 subunits of NF-kappaB complementary DNA encoded 542 and 555 amino acids, respectively. The p65 messenger RNA is highly expressed in the dog stomach and cat heart and adipose tissue.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NFKB1 elisa kitPathways associated with NFKB1 elisa kit
 Reference Product  PubMed Publications
 RELA elisa kit  >139 publications with NFKB1 and RELA
 IKBKB elisa kit  >52 publications with NFKB1 and IKBKB
 NFKBIA elisa kit  >45 publications with NFKB1 and NFKBIA
 IL6 elisa kit  >40 publications with NFKB1 and IL6
 IL1B elisa kit  >31 publications with NFKB1 and IL1B
 IL8 elisa kit  >21 publications with NFKB1 and IL8
 CHUK elisa kit  >16 publications with NFKB1 and CHUK
 MAP3K8 elisa kit  >11 publications with NFKB1 and MAP3K8
 EP300 elisa kit  >1 publications with NFKB1 and EP300
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 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
Diseases associated with NFKB1 elisa kitOrgans/Tissues associated with NFKB1 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >222 publications with NFKB1 and Inflammation
 Necrosis Antibodies  >140 publications with NFKB1 and Necrosis
 Cardiovascular Diseases Antibodies  >62 publications with NFKB1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >37 publications with NFKB1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >30 publications with NFKB1 and Nervous System Diseases
 Liver Diseases Antibodies  >27 publications with NFKB1 and Liver Diseases
 Adenocarcinoma Antibodies  >21 publications with NFKB1 and Adenocarcinoma
 Heart Diseases Antibodies  >18 publications with NFKB1 and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >15 publications with NFKB1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >14 publications with NFKB1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >10 publications with NFKB1 and Mixed
 Thyroid Antibodies  >6 publications with NFKB1 and Thyroid
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