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AVPR2 elisa kit :: Donkey Arginine Vasopressin Receptor 2 (AVPR2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9364485 AVPR2 elisa kit
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 Product Name   

Arginine Vasopressin Receptor 2 (AVPR2), ELISA Kit

 Also Known As   

Donkey Arginine Vasopressin Receptor 2 (AVPR2) ELISA Kit

 Product Gene Name   

AVPR2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    300538
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 Species Reactivity    Donkey
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AVPR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AVPR2 purchase    MBS9364485 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Arginine Vasopressin Receptor 2 (AVPR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AVPR2. The ELISA analytical biochemical technique of the MBS9364485 kit is based on AVPR2 antibody-AVPR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AVPR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AVPR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for AVPR2. It may not necessarily be applicable to this product.
 NCBI GI #    29825389
 NCBI GeneID    554
 NCBI Accession #    AAO92298.1 [Other Products]
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 UniProt Secondary Accession #    O43192; Q3MJD3; Q9UCV9; C5HF20 [Other Products]
 UniProt Related Accession #    P30518 [Other Products]
 Molecular Weight    33,743 Da
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 NCBI Official Full Name    arginine vasopressin receptor 2
 NCBI Official Synonym Full Names    arginine vasopressin receptor 2
 NCBI Official Symbol    AVPR2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    vasopressin V2 receptor
 UniProt Protein Name    Vasopressin V2 receptor
 UniProt Synonym Protein Names   
AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
 Protein Family    Vasopressin V2 receptor
 UniProt Gene Name    AVPR2 [Similar Products]
 UniProt Synonym Gene Names    ADHR; DIR; DIR3; V2R; V2R [Similar Products]
 UniProt Entry Name    V2R_HUMAN
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 NCBI Summary for AVPR2    This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AVPR2    AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Transporter, aquaporin family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum; endosome; Golgi apparatus; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: peptide binding; protein binding; vasopressin receptor activity

Biological Process: adenylate cyclase activation; cellular response to hormone stimulus; excretion; G-protein signaling, coupled to cAMP nucleotide second messenger; hemostasis; I-kappaB kinase/NF-kappaB cascade; interferon-gamma production; positive regulation of cell proliferation; positive regulation of protein ubiquitination; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; renal water homeostasis; response to cytokine stimulus; telencephalon development; transmembrane transport; water transport

Disease: Diabetes Insipidus, Nephrogenic, X-linked; Nephrogenic Syndrome Of Inappropriate Antidiuresis
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 Research Articles on AVPR2    1. Rescue of the N321K-V2R function by Val(4)-desmopressin action in nephrogenic diabetes insipidus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AVPR2 elisa kitPathways associated with AVPR2 elisa kit
 Reference Product  PubMed Publications
 AVP elisa kit  >53 publications with AVPR2 and AVP
 AQP2 elisa kit  >43 publications with AVPR2 and AQP2
 ARHGAP4 elisa kit  >8 publications with AVPR2 and ARHGAP4
 CLCNKA elisa kit  >2 publications with AVPR2 and CLCNKA
 HCFC1 elisa kit  >1 publications with AVPR2 and HCFC1
 TMEM187 elisa kit  >1 publications with AVPR2 and TMEM187
 RENBP elisa kit  >1 publications with AVPR2 and RENBP
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective AVP Causes Neurohypophyseal Diabetes Insipidus (NDI) Pathway antibodies  Defective AVP Causes Neurohypophyseal Diabetes Insipidus (NDI) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disorders Of Transmembrane Transporters Pathway antibodies  Disorders Of Transmembrane Transporters Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with AVPR2 elisa kitOrgans/Tissues associated with AVPR2 elisa kit
 Disease Name  Pubmed Publications
 Diabetes Insipidus, Nephrogenic Antibodies  >112 publications with AVPR2 and Diabetes Insipidus, Nephrogenic
 Kidney Diseases Antibodies  >98 publications with AVPR2 and Kidney Diseases
 Polyuria Antibodies  >34 publications with AVPR2 and Polyuria
 Hyponatremia Antibodies  >20 publications with AVPR2 and Hyponatremia
 Genetic Diseases, X-Linked Antibodies  >18 publications with AVPR2 and Genetic Diseases, X-Linked
 Nephrogenic Syndrome of Inappropriate Antidiuresis Antibodies  >13 publications with AVPR2 and Nephrogenic Syndrome of Inappropriate Antidiuresis
 Inappropriate ADH Syndrome Antibodies  >11 publications with AVPR2 and Inappropriate ADH Syndrome
 Disease Models, Animal Antibodies  >4 publications with AVPR2 and Disease Models, Animal
 Hypertension Antibodies  >2 publications with AVPR2 and Hypertension
 Nocturnal Enuresis Antibodies  >2 publications with AVPR2 and Nocturnal Enuresis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with AVPR2 and Lung
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