NP_476436.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,670 Da
NCBI Official Full Name
cytochrome P450 3A43 isoform 2
NCBI Official Synonym Full Names
cytochrome P450, family 3, subfamily A, polypeptide 43
NCBI Protein Information
cytochrome P450 3A43; cytochrome P450, subfamily IIIA, polypeptide 43
UniProt Protein Name
Cytochrome P450 3A43
UniProt Entry Name
CP343_HUMAN
NCBI Summary for CD74
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for CD74
CYP3A43: Exhibits low testosterone 6-beta-hydroxylase activity. Belongs to the cytochrome P450 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes; Lipid Metabolism - linoleic acid; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol
Chromosomal Location of Human Ortholog: 7q21.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: iron ion binding; heme binding; monooxygenase activity
Biological Process: xenobiotic metabolic process
Research Articles on CD74
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Products associated with CD74 elisa kit
Pathways associated with CD74 elisa kit
Diseases associated with CD74 elisa kit
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