NP_034422.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,089 Da
NCBI Official Full Name
glucokinase
NCBI Official Synonym Full Names
glucokinase
NCBI Official Synonym Symbols
Gk; GLK; HK4; HKIV; HXKP; MODY2; Gls006 [Similar Products]
NCBI Protein Information
glucokinase; HK IV; hexokinase 4; hexokinase-4; hexokinase-D; hexokinase type IV
UniProt Protein Name
Glucokinase
UniProt Synonym Protein Names
Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D
UniProt Synonym Gene Names
UniProt Entry Name
HXK4_MOUSE
UniProt Comments for GCK
GK: a glycolytic enzyme that catalyzes glucose metabolism in the liver and pancreatic beta cells. Acts as a ""glucose sensor"" in beta cells. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. Glucokinase traps glucose inside the cell by catalyzing its phosphorylation to produce glucose-6-phosphate. Has a lower affinity for glucose than the three other isozymes of hexokinase, allowing other organs such as the brain and muscles to have first call on glucose when its supply is limited. Unlike other hexokinases, glucokinase is not inhibited by glucose-6-phosphate. Glucokinase is found in the outer membrane compartment of mitochondria. May bind VDAC, suppressing mitochondrial function. Glucokinase transcription is induced by insulin, perhaps via the activation of Stat 5B. Mutant glucokinase causes a rare form of diabetes and may also play a role in type 2 diabetes. Three splice variant isoforms of human glucokinase have been described.
Protein type: Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.1.2; Carbohydrate Metabolism - galactose; Kinase, other; Mitochondrial
Cellular Component: nucleoplasm; mitochondrion; cell; cytoplasm; actin filament; cell cortex; nucleus; cytosol; basal cortex; secretory granule
Molecular Function: transferase activity; protein binding; hexokinase activity; magnesium ion binding; nucleotide binding; kinase activity; ADP binding; glucokinase activity; phosphotransferase activity, alcohol group as acceptor; protein phosphatase binding; ATP binding; glucose binding
Biological Process: glucose 6-phosphate metabolic process; positive regulation of glycogen biosynthetic process; lipid homeostasis; glucose homeostasis; NADP metabolic process; cellular response to glucose starvation; detection of glucose; elevation of cytosolic calcium ion concentration; negative regulation of gluconeogenesis; second-messenger-mediated signaling; glycogen biosynthetic process; glycolysis; regulation of potassium ion transport; glucose metabolic process; positive regulation of insulin secretion; fructose 2,6-bisphosphate metabolic process; cellular response to insulin stimulus; carbohydrate phosphorylation; carbohydrate metabolic process; positive regulation of glycolysis; negative regulation of epinephrine secretion; cell glucose homeostasis; phosphorylation; regulation of insulin secretion; positive regulation of phosphorylation
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Pathways associated with GCK elisa kit
Diseases associated with GCK elisa kit
Organs/Tissues associated with GCK elisa kit
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