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5-LO elisa kit :: Duck 5-Lipoxygenase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS101281 5-LO elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,575 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,055 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-Lipoxygenase (5-LO), ELISA Kit

 Also Known As   

Duck 5-Lipoxygenase ELISA Kit

 Product Gene Name   

5-LO elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Chromosome Location    Chromosome: 10; NC_000010.10 (45869624..45941567). Location: 10q11.2
 OMIM    152390
 3D Structure    ModBase 3D Structure for P09917
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 Species Reactivity    Duck
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes    Small volumes of 5-LO elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for 5-LO purchase    MBS101281 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5-Lipoxygenase (5-LO) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing 5-LO. The ELISA analytical biochemical technique of the MBS101281 kit is based on 5-LO antibody-5-LO antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect 5-LO antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, 5-LO. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for 5-LO. It may not necessarily be applicable to this product.
 NCBI GI #    187167
 NCBI GeneID    240
 NCBI Accession #    AAA63212.1 [Other Products]
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 UniProt Primary Accession #    P09917 [Other Products]
 UniProt Secondary Accession #    Q5JQ14; B7ZLS0 [Other Products]
 UniProt Related Accession #    P09917 [Other Products]
 Molecular Weight    77,983 Da
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 NCBI Official Full Name    5-lipoxygenase
 NCBI Official Synonym Full Names    arachidonate 5-lipoxygenase
 NCBI Official Symbol    ALOX5 [Similar Products]
 NCBI Official Synonym Symbols   
5-LO; 5LPG; LOG5; 5-LOX
[Similar Products]
 NCBI Protein Information    arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform
 UniProt Protein Name    Arachidonate 5-lipoxygenase
 UniProt Gene Name    ALOX5 [Similar Products]
 UniProt Synonym Gene Names    LOG5; 5-LO [Similar Products]
 UniProt Entry Name    LOX5_HUMAN
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 NCBI Summary for 5-LO    This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for 5-LO    5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.

Protein type: Oxidoreductase; EC 1.13.11.34; Nuclear envelope; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol

Molecular Function: protein binding; iron ion binding; arachidonate 5-lipoxygenase activity

Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process

Disease: Asthma, Susceptibility To
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 Research Articles on 5-LO    1. Data indicate that focal adhesion kinase (FAK) activation and cell migration require Src, Gi/Go, COX-2 and LOXs activities.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with 5-LO elisa kitPathways associated with 5-LO elisa kit
 Reference Product  PubMed Publications
 PTGS2 elisa kit  >255 publications with 5-LO and PTGS2
 ALOX5AP elisa kit  >195 publications with 5-LO and ALOX5AP
 PTGS1 elisa kit  >103 publications with 5-LO and PTGS1
 PLA2G4A elisa kit  >56 publications with 5-LO and PLA2G4A
 LTA4H elisa kit  >26 publications with 5-LO and LTA4H
 LTC4S elisa kit  >25 publications with 5-LO and LTC4S
 COTL1 elisa kit  >9 publications with 5-LO and COTL1
 MAPKAPK2 elisa kit  >7 publications with 5-LO and MAPKAPK2
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
Diseases associated with 5-LO elisa kitOrgans/Tissues associated with 5-LO elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >539 publications with 5-LO and Inflammation
 Neoplasms Antibodies  >308 publications with 5-LO and Neoplasms
 Asthma Antibodies  >237 publications with 5-LO and Asthma
 Lung Diseases Antibodies  >221 publications with 5-LO and Lung Diseases
 Atherosclerosis Antibodies  >113 publications with 5-LO and Atherosclerosis
 Necrosis Antibodies  >105 publications with 5-LO and Necrosis
 Edema Antibodies  >94 publications with 5-LO and Edema
 Drug Toxicity Antibodies  >88 publications with 5-LO and Drug Toxicity
 Neoplasms, Experimental Antibodies  >51 publications with 5-LO and Neoplasms, Experimental
 Pain Antibodies  >47 publications with 5-LO and Pain
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1096 publications with 5-LO and Blood
 Lung Antibodies  >244 publications with 5-LO and Lung
 Brain Antibodies  >121 publications with 5-LO and Brain
 Muscle Antibodies  >113 publications with 5-LO and Muscle
 Bone Antibodies  >75 publications with 5-LO and Bone
 Heart Antibodies  >67 publications with 5-LO and Heart
 Kidney Antibodies  >64 publications with 5-LO and Kidney
 Bone Marrow Antibodies  >56 publications with 5-LO and Bone Marrow
 Intestine Antibodies  >45 publications with 5-LO and Intestine
 Prostate Antibodies  >37 publications with 5-LO and Prostate
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