NP_001229832.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,342 Da
NCBI Official Full Name
A-kinase anchor protein 1, mitochondrial
NCBI Official Synonym Full Names
A kinase (PRKA) anchor protein 1
NCBI Official Synonym Symbols
AKAP; PRKA1; AKAP84; TDRD17; AKAP121; AKAP149; D-AKAP1; PPP1R43; SAKAP84 [Similar Products]
NCBI Protein Information
A-kinase anchor protein 1, mitochondrial; AKAP 149; D-AKAP-1; protein kinase A1; tudor domain containing 17; A-kinase anchor protein 149 kDa; protein kinase A anchoring protein 1; spermatid A-kinase anchor protein 84; protein phosphatase 1, regulatory subunit 43; dual-specificity A-kinase anchoring protein 1
UniProt Protein Name
A-kinase anchor protein 1, mitochondrial
UniProt Synonym Protein Names
A-kinase anchor protein 149 kDa; AKAP 149; Dual specificity A-kinase-anchoring protein 1; D-AKAP-1; Protein kinase A-anchoring protein 1; PRKA1; Spermatid A-kinase anchor protein 84
UniProt Synonym Gene Names
UniProt Entry Name
AKAP1_HUMAN
NCBI Summary for AKAP1
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
UniProt Comments for AKAP1
AKAP1: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Membrane protein, integral; RNA-binding; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: mitochondrial outer membrane; mitochondrion; membrane; integral to membrane; cytosol
Molecular Function: protein binding; RNA binding
Biological Process: blood coagulation
Research Articles on AKAP1
Precautions
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