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ACVR2B elisa kit :: Duck Activin Receptor Type-2B (ACVR2B) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9348738 ACVR2B elisa kit
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin Receptor Type-2B (ACVR2B), ELISA Kit

 Also Known As   

Duck Activin Receptor Type-2B (ACVR2B) ELISA Kit

 Product Gene Name   

ACVR2B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    602730
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 Species Reactivity    Duck
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACVR2B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACVR2B purchase    MBS9348738 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activin Receptor Type-2B (ACVR2B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACVR2B. The ELISA analytical biochemical technique of the MBS9348738 kit is based on ACVR2B antibody-ACVR2B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACVR2B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACVR2B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACVR2B. It may not necessarily be applicable to this product.
 NCBI GI #    116734708
 NCBI GeneID    93
 NCBI Accession #    NP_001097.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001106.3 [Other Products]
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 UniProt Secondary Accession #    Q4VAV0 [Other Products]
 UniProt Related Accession #    Q13705 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    activin receptor type-2B
 NCBI Official Synonym Full Names    activin A receptor type 2B
 NCBI Official Symbol    ACVR2B [Similar Products]
 NCBI Official Synonym Symbols   
HTX4; ACTRIIB; ActR-IIB
[Similar Products]
 NCBI Protein Information    activin receptor type-2B
 UniProt Protein Name    Activin receptor type-2B
 UniProt Synonym Protein Names   
Activin receptor type IIB; ACTR-IIB
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR2B [Similar Products]
 UniProt Synonym Gene Names    ACTR-IIB [Similar Products]
 UniProt Entry Name    AVR2B_HUMAN
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 NCBI Summary for ACVR2B    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACVR2B    ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; Protein kinase, TKL; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane; protein complex; receptor complex

Molecular Function: activin binding; activin receptor activity, type II; ATP binding; growth factor binding; metal ion binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of protein kinase activity; activin receptor signaling pathway; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; determination of left/right symmetry; embryonic foregut morphogenesis; gastrulation with mouth forming second; heart development; insulin secretion; kidney development; lung development; lymphangiogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; organ growth; palate development; pancreas development; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; post-embryonic development; regulation of transcription, DNA-dependent; response to glucose stimulus; signal transduction; skeletal morphogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway

Disease: Heterotaxy, Visceral, 4, Autosomal
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 Research Articles on ACVR2B    1. Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACVR2B elisa kitPathways associated with ACVR2B elisa kit
 Reference Product  PubMed Publications
 SMAD2 elisa kit  >14 publications with ACVR2B and SMAD2
 MSTN elisa kit  >12 publications with ACVR2B and MSTN
 BMP2 elisa kit  >9 publications with ACVR2B and BMP2
 SMAD3 elisa kit  >8 publications with ACVR2B and SMAD3
 BMPR1A elisa kit  >7 publications with ACVR2B and BMPR1A
 SMAD5 elisa kit  >3 publications with ACVR2B and SMAD5
 ACVR1B elisa kit  >2 publications with ACVR2B and ACVR1B
 ACVRL1 elisa kit  >1 publications with ACVR2B and ACVRL1
 INHBA elisa kit  >1 publications with ACVR2B and INHBA
 Products by Pathway  Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
Diseases associated with ACVR2B elisa kitOrgans/Tissues associated with ACVR2B elisa kit
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >10 publications with ACVR2B and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >7 publications with ACVR2B and Cardiovascular Diseases
 Hypertrophy Antibodies  >5 publications with ACVR2B and Hypertrophy
 Disease Models, Animal Antibodies  >4 publications with ACVR2B and Disease Models, Animal
 Nervous System Diseases Antibodies  >4 publications with ACVR2B and Nervous System Diseases
 Situs Inversus Antibodies  >4 publications with ACVR2B and Situs Inversus
 Inflammation Antibodies  >3 publications with ACVR2B and Inflammation
 Heterotaxy Syndrome Antibodies  >3 publications with ACVR2B and Heterotaxy Syndrome
 Kidney Diseases Antibodies  >2 publications with ACVR2B and Kidney Diseases
 Weight Loss Antibodies  >2 publications with ACVR2B and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >6 publications with ACVR2B and Heart
 Kidney Antibodies  >5 publications with ACVR2B and Kidney
 Ovary Antibodies  >5 publications with ACVR2B and Ovary
 Embryonic Tissue Antibodies  >5 publications with ACVR2B and Embryonic Tissue
 Connective Tissue Antibodies  >4 publications with ACVR2B and Connective Tissue
 Lung Antibodies  >3 publications with ACVR2B and Lung
 Testis Antibodies  >2 publications with ACVR2B and Testis
 Brain Antibodies  >2 publications with ACVR2B and Brain
 Pancreas Antibodies  >2 publications with ACVR2B and Pancreas
 Pituitary Gland Antibodies  >1 publications with ACVR2B and Pituitary Gland
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