NP_001032588.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8,318 Da
NCBI Official Full Name
beta-defensin 114
NCBI Official Synonym Full Names
defensin beta 114
NCBI Protein Information
beta-defensin 114
UniProt Protein Name
Beta-defensin 114
UniProt Synonym Protein Names
Beta-defensin 14; DEFB-14; Defensin, beta 114
UniProt Synonym Gene Names
UniProt Entry Name
DB114_HUMAN
NCBI Summary for DEFB114
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. The protein encoded by this gene is a beta-defensin with antimicrobial activity against E. coli, S. aureus, and C. albicans. The encoded protein also binds and neutralizes lipopolysaccharide (LPS), a factor involved in inflammatory diseases and male reproductive issues. [provided by RefSeq, Nov 2014]
UniProt Comments for DEFB114
DEFB114: Has antibacterial activity. Belongs to the beta-defensin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12.3
Cellular Component: extracellular region
Molecular Function: lipopolysaccharide binding
Biological Process: defense response to bacterium; negative regulation of lipopolysaccharide-mediated signaling pathway
Research Articles on DEFB114
Precautions
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Pathways associated with DEFB114 elisa kit
Diseases associated with DEFB114 elisa kit
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