NP_001093259.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,654 Da
NCBI Official Full Name
intercellular adhesion molecule 2
NCBI Official Synonym Full Names
intercellular adhesion molecule 2
NCBI Official Synonym Symbols
NCBI Protein Information
intercellular adhesion molecule 2; ICAM-2
UniProt Protein Name
Intercellular adhesion molecule 2
UniProt Synonym Gene Names
UniProt Entry Name
ICAM2_HUMAN
NCBI Summary for ICAM-2
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ICAM-2
ICAM2: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Belongs to the immunoglobulin superfamily. ICAM family.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: membrane; integral to plasma membrane; plasma membrane; uropod
Molecular Function: integrin binding
Biological Process: cell-cell adhesion; extracellular matrix organization and biogenesis; regulation of immune response; cell adhesion
Research Articles on ICAM-2
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Products associated with ICAM-2 elisa kit
Pathways associated with ICAM-2 elisa kit
Diseases associated with ICAM-2 elisa kit
Organs/Tissues associated with ICAM-2 elisa kit
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