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PRE-alpha2 MG elisa kit :: Duck alpha2 Macroglobulin Precursor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS083883 PRE-alpha2 MG elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

alpha2 Macroglobulin Precursor (PRE-alpha2 MG), ELISA Kit

★Popular Item★
 Also Known As   

Duck alpha2 Macroglobulin Precursor ELISA Kit

 Product Gene Name   

PRE-alpha2 MG elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 12; NC_000012.11 (9220304..9268558, complement). Location: 12p13.31
 OMIM    103950
 3D Structure    ModBase 3D Structure for P01023
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 Species Reactivity    Duck
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    125 ug/ml - 4000 ug/ml
 Sensitivity    10 ug/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PRE-alpha2 MG elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PRE-alpha2 MG purchase    MBS083883 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the alpha2 Macroglobulin Precursor (PRE-alpha2 MG) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 125 ug/ml - 4000 ug/ml in biological research samples containing PRE-alpha2 MG, with an estimated sensitivity of 10 ug/ml. The ELISA analytical biochemical technique of the MBS083883 kit is based on PRE-alpha2 MG antibody-PRE-alpha2 MG antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PRE-alpha2 MG antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PRE-alpha2 MG. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PRE-alpha2 MG elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of A2MGP (hereafter termed "analyte") in undiluted original Duck body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS083883. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PRE-alpha2 MG. It may not necessarily be applicable to this product.
 NCBI GI #    66932947
 NCBI GeneID    2
 NCBI Accession #    NP_000005.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000014.4 [Other Products]
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 UniProt Primary Accession #    P01023 [Other Products]
 UniProt Secondary Accession #    Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97 [Other Products]
 UniProt Related Accession #    P01023 [Other Products]
 Molecular Weight    163,291 Da
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 NCBI Official Full Name    alpha-2-macroglobulin
 NCBI Official Synonym Full Names    alpha-2-macroglobulin
 NCBI Official Symbol    A2M [Similar Products]
 NCBI Official Synonym Symbols   
A2MD; CPAMD5; FWP007; S863-7
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 UniProt Protein Name    Alpha-2-macroglobulin
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 UniProt Gene Name    A2M [Similar Products]
 UniProt Synonym Gene Names    CPAMD5; Alpha-2-M [Similar Products]
 UniProt Entry Name    A2MG_HUMAN
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 NCBI Summary for PRE-alpha2 MG    Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRE-alpha2 MG    A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular region; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-8 binding; interleukin-1 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; extracellular matrix disassembly; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway

Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
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 Research Articles on PRE-alpha2 MG    1. [review] alpha2M has many diversified and complex functions but is primarily known by its ability to inhibit a broad spectrum of proteases without the direct blockage of the protease active site.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRE-alpha2 MG elisa kitPathways associated with PRE-alpha2 MG elisa kit
 Reference Product  PubMed Publications
 APP elisa kit  >15 publications with PRE-alpha2 MG and APP
 LRP1 elisa kit  >11 publications with PRE-alpha2 MG and LRP1
 ALB elisa kit  >6 publications with PRE-alpha2 MG and ALB
 TGFB1 elisa kit  >2 publications with PRE-alpha2 MG and TGFB1
 FN1 elisa kit  >1 publications with PRE-alpha2 MG and FN1
 PLG elisa kit  >1 publications with PRE-alpha2 MG and PLG
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
Diseases associated with PRE-alpha2 MG elisa kitOrgans/Tissues associated with PRE-alpha2 MG elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >89 publications with PRE-alpha2 MG and Nervous System Diseases
 Brain Diseases Antibodies  >85 publications with PRE-alpha2 MG and Brain Diseases
 Mental Disorders Antibodies  >79 publications with PRE-alpha2 MG and Mental Disorders
 Alzheimer Disease Antibodies  >76 publications with PRE-alpha2 MG and Alzheimer Disease
 Neoplasms Antibodies  >31 publications with PRE-alpha2 MG and Neoplasms
 Inflammation Antibodies  >28 publications with PRE-alpha2 MG and Inflammation
 Necrosis Antibodies  >14 publications with PRE-alpha2 MG and Necrosis
 Liver Diseases Antibodies  >12 publications with PRE-alpha2 MG and Liver Diseases
 Fibrosis Antibodies  >11 publications with PRE-alpha2 MG and Fibrosis
 Lung Diseases Antibodies  >11 publications with PRE-alpha2 MG and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >119 publications with PRE-alpha2 MG and Blood
 Liver Antibodies  >35 publications with PRE-alpha2 MG and Liver
 Brain Antibodies  >29 publications with PRE-alpha2 MG and Brain
 Vascular Antibodies  >13 publications with PRE-alpha2 MG and Vascular
 Lung Antibodies  >10 publications with PRE-alpha2 MG and Lung
 Prostate Antibodies  >9 publications with PRE-alpha2 MG and Prostate
 Heart Antibodies  >8 publications with PRE-alpha2 MG and Heart
 Uterus Antibodies  >6 publications with PRE-alpha2 MG and Uterus
 Placenta Antibodies  >5 publications with PRE-alpha2 MG and Placenta
 Embryonic Tissue Antibodies  >5 publications with PRE-alpha2 MG and Embryonic Tissue
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