NP_000656.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,352 Da
NCBI Official Full Name
acetylcholinesterase isoform E4-E6
NCBI Official Synonym Full Names
acetylcholinesterase (Cartwright blood group)
NCBI Protein Information
acetylcholinesterase
UniProt Protein Name
Acetylcholinesterase
UniProt Synonym Gene Names
NCBI Summary for ACHE
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
UniProt Comments for ACHE
AChE: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs to the type-B carboxylesterase/lipase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.1.7; Hydrolase; Lipid Metabolism - glycerophospholipid; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: basal lamina; cell junction; cell surface; extracellular region; extracellular space; Golgi apparatus; membrane; neuromuscular junction; nucleus; perinuclear region of cytoplasm; plasma membrane; synapse
Molecular Function: acetylcholine binding; acetylcholinesterase activity; amyloid-beta binding; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; protein homodimerization activity; protein self-association; serine hydrolase activity
Biological Process: acetylcholine catabolic process; acetylcholine catabolic process in synaptic cleft; amyloid precursor protein metabolic process; cell adhesion; cell proliferation; DNA replication; muscle organ development; negative regulation of synaptic transmission, cholinergic; nervous system development; neurotransmitter biosynthetic process; neurotransmitter receptor biosynthetic process; osteoblast development; phosphatidylcholine biosynthetic process; positive regulation of protein secretion; protein tetramerization; receptor internalization; regulation of receptor recycling; response to wounding; retina development in camera-type eye; synaptogenesis
Disease: Yt Blood Group Antigen
Research Articles on ACHE
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Products associated with ACHE elisa kit
Pathways associated with ACHE elisa kit
Diseases associated with ACHE elisa kit
Organs/Tissues associated with ACHE elisa kit
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