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AXIN elisa kit :: Fish Axis Inhibition Protein ELISA Kit

Scan QR to view Datasheet Catalog #    MBS035946 AXIN elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Axis Inhibition Protein (AXIN), ELISA Kit

 Also Known As   

Fish Axis Inhibition Protein ELISA Kit

 Product Gene Name   

AXIN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 16; NC_000016.9 (337440..402676, complement). Location: 16p13.3
 OMIM    114550
 3D Structure    ModBase 3D Structure for O15169
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 Species Reactivity    Fish
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AXIN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AXIN purchase    MBS035946 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Axis Inhibition Protein (AXIN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AXIN. The ELISA analytical biochemical technique of the MBS035946 kit is based on AXIN antibody-AXIN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AXIN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AXIN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for AXIN. It may not necessarily be applicable to this product.
 NCBI GI #    2252820
 NCBI GeneID    8312
 NCBI Accession #    AAC51624.1 [Other Products]
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 UniProt Primary Accession #    O15169 [Other Products]
 UniProt Secondary Accession #    Q4TT26; Q4TT27; Q86YA7; Q8WVW6; Q96S28 [Other Products]
 UniProt Related Accession #    O15169 [Other Products]
 Molecular Weight    95,635 Da
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 NCBI Official Full Name    axin
 NCBI Official Synonym Full Names    axin 1
 NCBI Official Symbol    AXIN1 [Similar Products]
 NCBI Official Synonym Symbols   
AXIN; PPP1R49
[Similar Products]
 NCBI Protein Information    axin-1; axis inhibitor 1; fused, mouse, homolog of; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49
 UniProt Protein Name    Axin-1
 UniProt Synonym Protein Names   
Axis inhibition protein 1
 UniProt Gene Name    AXIN1 [Similar Products]
 UniProt Synonym Gene Names    AXIN; hAxin [Similar Products]
 UniProt Entry Name    AXIN1_HUMAN
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 NCBI Summary for AXIN    This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for AXIN    axin 1: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin-1 functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Wild-type axin 1 can induce apoptosis in hepatocellular and colorectal cancer cells. Is downregulated during progression of esophageal squamous cell carcinoma. Mutation of the axin-1 gene is associated with hepatocellular carcinoma, anaplastic thyroid cancer, medulloblastoma and colorectal cancer. May have a role in oncogenesis in Hodgkin lymphoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.

Protein type: Adaptor/scaffold; Tumor suppressor

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasm; cytoplasmic membrane-bound vesicle; postsynaptic density; cell cortex; cytoplasmic vesicle; cytosol; beta-catenin destruction complex; nucleus; lateral plasma membrane

Molecular Function: protein C-terminus binding; identical protein binding; protein homodimerization activity; protein self-association; p53 binding; beta-catenin binding; protein kinase binding; GTPase activator activity; signal transducer activity; protein binding; enzyme binding; receptor signaling complex scaffold activity; ubiquitin protein ligase binding; protein complex scaffold; SMAD binding; receptor binding

Biological Process: cell death; protein polyubiquitination; negative regulation of Wnt receptor signaling pathway; embryonic eye morphogenesis; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; negative regulation of protein metabolic process; dorsal/ventral axis specification; nucleocytoplasmic transport; Wnt receptor signaling pathway through beta-catenin; olfactory placode formation; activation of JNK activity; cytoplasmic microtubule organization and biogenesis; sensory perception of sound; positive regulation of ubiquitin-protein ligase activity; Wnt receptor signaling pathway involved in forebrain neuron fate commitment; protein catabolic process; protein homooligomerization; axial mesoderm formation; in utero embryonic development; muscle cell development; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of fat cell differentiation; positive regulation of peptidyl-serine phosphorylation; optic placode formation; cellular protein complex assembly; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; forebrain anterior/posterior pattern formation; positive regulation of protein catabolic process; activation of protein kinase activity; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; positive regulation of GTPase activity

Disease: Caudal Duplication Anomaly; Hepatocellular Carcinoma
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 Research Articles on AXIN    1. X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory effect of HDAC on Axin, upregulate Axin expression and induce apoptosis of lung cancer cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AXIN elisa kitPathways associated with AXIN elisa kit
 Reference Product  PubMed Publications
 CTNNB1 elisa kit  >160 publications with AXIN and CTNNB1
 APC elisa kit  >76 publications with AXIN and APC
 LRP5 elisa kit  >12 publications with AXIN and LRP5
 LRP6 elisa kit  >12 publications with AXIN and LRP6
 GSK3B elisa kit  >3 publications with AXIN and GSK3B
 DVL1 elisa kit  >2 publications with AXIN and DVL1
 MAP3K1 elisa kit  >2 publications with AXIN and MAP3K1
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram
Diseases associated with AXIN elisa kitOrgans/Tissues associated with AXIN elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >86 publications with AXIN and Neoplasms
 Adenocarcinoma Antibodies  >26 publications with AXIN and Adenocarcinoma
 Liver Diseases Antibodies  >21 publications with AXIN and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >21 publications with AXIN and Carcinoma, Hepatocellular
 Musculoskeletal Diseases Antibodies  >8 publications with AXIN and Musculoskeletal Diseases
 Brain Diseases Antibodies  >7 publications with AXIN and Brain Diseases
 Nervous System Diseases Antibodies  >6 publications with AXIN and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with AXIN and Disease Models, Animal
 Endometrial Neoplasms Antibodies  >4 publications with AXIN and Endometrial Neoplasms
 Ovarian Diseases Antibodies  >4 publications with AXIN and Ovarian Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >27 publications with AXIN and Liver
 Brain Antibodies  >17 publications with AXIN and Brain
 Bone Antibodies  >11 publications with AXIN and Bone
 Eye Antibodies  >8 publications with AXIN and Eye
 Embryonic Tissue Antibodies  >7 publications with AXIN and Embryonic Tissue
 Lung Antibodies  >6 publications with AXIN and Lung
 Blood Antibodies  >5 publications with AXIN and Blood
 Mouth Antibodies  >5 publications with AXIN and Mouth
 Muscle Antibodies  >4 publications with AXIN and Muscle
 Intestine Antibodies  >4 publications with AXIN and Intestine
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